The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants
about
The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiencyKu regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cellsInteractome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathwayMouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage fociPARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathwaysIndependent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54Developmental modulation of nonhomologous end joining in Caenorhabditis elegans.DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.Choosing the right path: does DNA-PK help make the decision?BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeresA Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblastsThe role of DNA breaks in genomic instability and tumorigenesis.Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.The role of the non-homologous end-joining pathway in lymphocyte development.Alternative endings.Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous endsDNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.Mouse models of DNA double-strand break repair and neurological diseaseImpaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.Synthetic lethality between PAXX and XLF in mammalian development.PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.Collaboration and competition between DNA double-strand break repair pathways.Functional overlaps between XLF and the ATM-dependent DNA double strand break response.Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes.Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity.Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting.DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.Nonhomologous DNA end joining in cell-free extracts.Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaksNonhomologous DNA End Joining for Repair of DNA Double-Strand Breaks.Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.
P2860
Q21132271-3BF3907E-584A-462E-B8BE-ED93AA5A7499Q21563320-7563BCAB-B8E4-4DCD-8273-839F52B4A161Q24318661-D181DF88-4C98-4FD5-B18A-04992AFA1DB6Q24599990-91B3F4BD-0548-4FFD-ADB2-C927D7ABD0FDQ24815695-5BF54C52-3D17-4150-AD9A-9D57B723F1A9Q28116217-7D027EBA-003C-4458-AE39-B795AB9C6D93Q29616041-0C16A9DB-B7B1-422C-95FD-1034EB321B0DQ33220843-34E07AA6-B62B-4C73-8AEA-BE9E95766026Q33540945-2C3E5C01-9B67-401B-A012-6BFE2055DE47Q33656097-5FC2C590-1790-46F3-9495-27ED6A7201D0Q33878468-54280356-7D4F-4DD9-BD0E-C930A949C604Q34619414-604B648B-5633-42A5-B192-0997F40925F3Q34897855-76BA394C-759A-4682-B0E2-1EC4A3224EEBQ34965038-8D8C4391-A52F-4DFD-B7F2-33CF17DF9F17Q35029335-F903D5A0-730D-4BA1-9B1B-57B01E6B77B6Q35116646-267E5002-096C-4F7F-BF44-666797A937DBQ35131190-9F8BF7A0-1FB0-4220-919C-6EC23F1D96C0Q35170919-A92F1FB7-CE39-4627-A4EE-F278022FA079Q35555378-D3F249F2-E0AB-4788-8BFB-40A34919CCFEQ35830410-585477BA-FBDA-4DA2-AC4D-BB5E81B80AEDQ36392830-EC335DBE-AF58-462B-A127-C2DA7807EC92Q36649664-B77E8417-5AAB-4A4F-A653-924463CC0EC4Q36693356-D494EDF1-FA75-42E0-A444-B70B40C85600Q36998015-70766FE3-4CD0-474E-80C7-81B0471F3591Q37155146-3D85AB62-0580-4826-9362-ECC7F703C4D0Q37209237-9C0232B9-052B-4552-A19B-022FF3E3E4CFQ37383233-2A256987-309D-4451-89C2-838F597E74A0Q37562697-9ADE0018-8919-4A5E-A05C-B69F88173B07Q37638191-A2448B07-8E72-418A-85B5-7776EDB31FCCQ38199848-6804BFAD-5715-445D-8E6D-5A31DF33C312Q38321939-70196352-FD69-44A0-83CF-07D66EA6CD17Q38684468-FEF9AACA-6DE1-48E0-9C49-B03F61658295Q39481658-03C0B422-DD01-4D77-BBB9-9D0C40BA9857Q39932479-F8A32753-2502-40AA-9DD6-C1430AC241F1Q40497393-ED2629F5-DBCC-49BF-9CB7-4E486A603FACQ41135252-F2241230-9CD7-4E48-BEA6-51B66950B399Q42030919-F3EBAEF2-4F9C-42BD-BCB0-C7FEBC1B0C1CQ42078607-4197160F-217C-42F1-AE1E-FF2A434E610AQ47287487-A3ADE1B3-4120-45E2-97C2-47F10520A3E3Q48008495-5F8B0C91-3D33-4F52-97CD-0CEA08E8E652
P2860
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/12/05)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/05)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في 5-12-2002)
@ar
name
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@ast
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@en
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@nl
type
label
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@ast
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@en
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@nl
prefLabel
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@ast
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@en
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@nl
P2093
P1433
P1476
The embryonic lethality in DNA ...... ous phenotypes of NHEJ mutants
@en
P2093
Chih-Lin Hsieh
Darryl Shibata
Klaus Schwarz
Michael R. Lieber
Noritaka Adachi
Ryan A. Irvine
Zarir E. Karanjawala
P304
P356
10.1016/S1568-7864(02)00151-9
P577
2002-12-05T00:00:00Z