Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideSilencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's miceNeuroprotective Mechanisms Mediated by CDK5 InhibitionGlutamate receptor ion channels: structure, regulation, and functionInvolvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injuryCdk5 phosphorylates dopamine D2 receptor and attenuates downstream signalingTFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic strokeDelayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke modelsDAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in strokeCombinations of Kinase Inhibitors Protecting Myoblasts against HypoxiaCdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicityDifferential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neuronsAstrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.Synaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyDirect effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.Deregulation of HDAC1 by p25/Cdk5 in neurotoxicityProtection after stroke: cellular effectors of neurovascular unit integrity.Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's miceActin interaction and regulation of cyclin-dependent kinase 5/p35 complex activitySignaling cascades regulating NMDA receptor sensitivity to ethanol.DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors.Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neuronsAt the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action.Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration.The role of Cdk5 in cognition and neuropsychiatric and neurological pathology.Zebrafish Rohon-Beard neuron development: cdk5 in the midst.Neuroprotective strategies against calpain-mediated neurodegeneration.Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrusSynaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing.EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegansRegulation of NMDA receptors by phosphorylation.Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegenerationEffects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseNegative regulation of cyclin-dependent kinase 5 targets by protein kinase C
P2860
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P2860
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/01)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
مقالة علمية (نشرت في أكتوبر 2003)
@ar
name
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@ast
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@en
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@nl
type
label
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@ast
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@en
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@nl
prefLabel
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@ast
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@en
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@nl
P2093
P2860
P356
P1433
P1476
Cdk5 activation induces hippoc ...... phosphorylating NMDA receptors
@en
P2093
Jerry H. Wang
ShuHong Liu
YangPing Fu
YouMing Lu
P2860
P2888
P304
P356
10.1038/NN1119
P407
P577
2003-10-01T00:00:00Z