Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
about
Unraveling the complex metabolic nature of astrocytesA decade of the anaphase-promoting complex in the nervous system6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27Interplay between oxidant species and energy metabolismEnhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila modelThe Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of RatsAstrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.Glucose and Intermediary Metabolism and Astrocyte-Neuron Interactions Following Neonatal Hypoxia-Ischemia in Rat.Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cellsPathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.p53 and mitochondrial function in neurons.Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neuronsStructure-based design of small-molecule ligands of phosphofructokinase-2 activating or inhibiting glycolysis.Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical ReactionsDifferential expression of glucose-metabolizing enzymes in multiple sclerosis lesions.Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury.A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease.The metabolic response to excitotoxicity - lessons from single-cell imaging.Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.Bioenergetics and redox adaptations of astrocytes to neuronal activity.Mitochondrial control of cell bioenergetics in Parkinson's disease.Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion.Near-critical GLUT1 and Neurodegeneration.Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes.A disease with a sweet tooth: exploring the Warburg effect in Alzheimer's disease.New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytesPhosphofructokinase-1 Negatively Regulates Neurogenesis from Neural Stem Cells.Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione.Underestimation of the pentose-phosphate pathway in intact primary neurons as revealed by metabolic flux analysis.Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H2O2 Depuration.α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list: An Editorial highlight for 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?'6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
P2860
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P2860
Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@ast
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@en
type
label
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@ast
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@en
prefLabel
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@ast
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@en
P2860
P356
P1476
Excitotoxic stimulus stabilize ...... s switch and neurodegeneration
@en
P2093
E Fernandez
J P Bolaños
P2860
P2888
P304
P356
10.1038/CDD.2012.33
P577
2012-03-16T00:00:00Z