Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
about
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionLoss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damagePrevention of DNA re-replication in eukaryotic cellsPreventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1Mechanisms for initiating cellular DNA replicationGenomic instability in cancer.Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factorsQuaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingStructure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm ProteinsStructural basis for homeodomain recognition by the cell-cycle regulator GemininMcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil DomainThe Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication LicensingRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityHBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by GemininHelicase loading at chromosomal origins of replicationGene Expression Profiling of Primary Cutaneous Melanoma and Clinical OutcomeCell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Geminin inhibits a late step in the formation of human pre-replicative complexes.Archaeology of eukaryotic DNA replicationCdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation.Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placentaAdenovirus replaces mitotic checkpoint controls.Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicasesThe Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complexStealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy.The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.An inactive geminin mutant that binds cdt1Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication.Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating GemininThe Expression and Prognostic Roles of MCMs in Pancreatic Cancer.Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners.Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertilityCharacterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Gene expression profiling and clinical outcome in melanoma: in search of novel prognostic factors.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.
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P2860
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2004
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scientific journal article
@en
vedecký článok (publikovaný 2004/08/19)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/19)
@nl
наукова стаття, опублікована в серпні 2004
@uk
مقالة علمية (نشرت في 19-8-2004)
@ar
name
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@ast
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@en
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@nl
type
label
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@ast
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@en
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@nl
prefLabel
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@ast
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@en
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@nl
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Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
@en
P2093
BumSoo Hong
Changwook Lee
Jung Min Choi
Saori Watanabe
Shusuke Tada
Takemi Enomoto
Youngchang Kim
Yugene Kim
Yukio Ishimi
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P2888
P304
P3181
P356
10.1038/NATURE02813
P407
P577
2004-08-19T00:00:00Z
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P6179
1025683200