Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
about
The HTLV-1 Tax interactomeC-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinaseThe p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteinsThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexSemaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathwayRoles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gammaFBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeTwo distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiationHepatitis C virus infection and type 1 and type 2 diabetes mellitusPhosphoinositides: tiny lipids with giant impact on cell regulationMultiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesisReduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetesPI3K at the crossroads of tumor angiogenesis signaling pathwaysPositive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signalingp85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiationMaternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspringp85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB responsePhosphoinositide 3-kinase p85beta regulates invadopodium formation.Regulation of the PI3K pathway through a p85α monomer-homodimer equilibriumDirect positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevityBiological effects of growth hormone on carbohydrate and lipid metabolism.Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscleBRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3KPhosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determinationModulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinaseRecognizing and exploiting differences between RNAi and small-molecule inhibitors.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthGene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseasesOncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinaseHeterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3Kp50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.Molecular mechanisms of insulin resistance in type 2 diabetes mellitusPhosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains
P2860
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P2860
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Molecular balance between the ...... s cell signaling and survival.
@ast
Molecular balance between the ...... s cell signaling and survival.
@en
Molecular balance between the ...... s cell signaling and survival.
@nl
type
label
Molecular balance between the ...... s cell signaling and survival.
@ast
Molecular balance between the ...... s cell signaling and survival.
@en
Molecular balance between the ...... s cell signaling and survival.
@nl
prefLabel
Molecular balance between the ...... s cell signaling and survival.
@ast
Molecular balance between the ...... s cell signaling and survival.
@en
Molecular balance between the ...... s cell signaling and survival.
@nl
P2093
P2860
P1476
Molecular balance between the ...... s cell signaling and survival.
@en
P2093
David A Fruman
Lewis C Cantley
Saskia M Brachmann
Yu-Hua Tseng
P2860
P304
P356
10.1128/MCB.22.3.965-977.2002
P407
P577
2002-02-01T00:00:00Z