Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism
about
The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted geneGene Dosage Effects at the Imprinted Gnas ClusterTransgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivoMaternal inheritance of the Gnas cluster mutation Ex1A-T affects size, implicating NESP55 in growthMyostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.Imprinted Nesp55 influences behavioral reactivity to novel environmentsDNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traitsA patient with features of albright hereditory osteodystrophy and unusual neuropsychiatric findings without coding Gsalpha mutationsAlternative Gnas gene products have opposite effects on glucose and lipid metabolism.Identification of a methylation imprint mark within the mouse Gnas locus.The role of GNAS and other imprinted genes in the development of obesity.In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.The role of genomic imprinting in biology and disease: an expanding view.A GNAS1 imprinting defect in pseudohypoparathyroidism type IBThe alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult miceCold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liverEffects of deficiency of the G protein Gsα on energy and glucose homeostasisLessons in obesity from transgenic animals.Transcription driven somatic DNA methylation within the imprinted Gnas clusterTranscriptomic analysis of brown adipose tissue across the physiological extremes of natural hibernationControl of body weight: a physiologic and transgenic perspective.Increased methylation at differentially methylated region of GNAS in infants born to gestational diabetes.Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signalingAnti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°CNew mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling.Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Paternally inherited gsα mutation impairs adipogenesis and potentiates a lean phenotype in vivo.Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy.G proteins in development.Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production.Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted TranscriptsCentral nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.Physiological dysfunctions associated with mutations of the imprinted Gnas locus.Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo.Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.Regulation, Signaling, and Physiological Functions of G-Proteins.
P2860
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P2860
Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism
description
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/03/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/03/01)
@nl
наукова стаття, опублікована в березні 2000
@uk
مقالة علمية (نشرت في مارس 2000)
@ar
name
Paternal versus maternal trans ...... e effects on energy metabolism
@ast
Paternal versus maternal trans ...... e effects on energy metabolism
@en
Paternal versus maternal trans ...... e effects on energy metabolism
@nl
type
label
Paternal versus maternal trans ...... e effects on energy metabolism
@ast
Paternal versus maternal trans ...... e effects on energy metabolism
@en
Paternal versus maternal trans ...... e effects on energy metabolism
@nl
prefLabel
Paternal versus maternal trans ...... e effects on energy metabolism
@ast
Paternal versus maternal trans ...... e effects on energy metabolism
@en
Paternal versus maternal trans ...... e effects on energy metabolism
@nl
P2093
P2860
P356
P1476
Paternal versus maternal trans ...... e effects on energy metabolism
@en
P2093
A. F. Parlow
L. S. Weinstein
M. J. Quon
M. L. Reitman
O. Gavrilova
P2860
P304
P356
10.1172/JCI8437
P407
P577
2000-03-01T00:00:00Z