Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
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The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαThe schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseSelf-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathwayClarifying lysosomal storage diseasesPhosphoinositides: tiny lipids with giant impact on cell regulationYeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1.The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampusCalcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriersA model selection approach to discover age-dependent gene expression patterns using quantile regression models.SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading.A balancing act for autophaginAn AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.Topological and functional properties of the small GTPases protein interaction network.MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Mechanisms of protein delivery to melanosomes in pigment cells.Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesiclesThe Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the SynapseQuantitative Map of Proteome Dynamics during Neuronal Differentiation.Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?Synaptic vesicle endocytosis.Hypopigmentation in Hermansky-Pudlak syndrome.Storage pool diseases illuminate platelet dense granule biogenesis.Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice
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P2860
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
description
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2009
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im März 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2009/03/01)
@sk
vědecký článek publikovaný v roce 2009
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wetenschappelijk artikel (gepubliceerd op 2009/03/01)
@nl
наукова стаття, опублікована в березні 2009
@uk
مقالة علمية (نشرت في مارس 2009)
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name
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@ast
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@en
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
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type
label
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@ast
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@en
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@nl
prefLabel
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@ast
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@en
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
@nl
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P3181
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P1476
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles
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P2093
Gloria Salazar
Yoland Smith
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P304
P3181
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10.1091/MBC.E08-05-0456
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2009-03-01T00:00:00Z