Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes - Wikidata - awgldk - TriplyDB

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

http://www.wikidata.org/entity/Q28611364

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Raf family kinases: old dogs have learned new tricks The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.Growth control by intracellular tension and extracellular stiffness Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.RETRACTED: TGFβ1 activates c-Jun and Erk1 via αVβ6 integrin Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1 ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration RabGEF1 is a negative regulator of mast cell activation and skin inflammation Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration Mek2 is dispensable for mouse growth and development Serotonin Receptor 4/6/7 and NR3C Signaling Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory MEK1 activation by PAK: a novel mechanism.Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2.LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.Potential compensation among group I PAK members in hindlimb ischemia and wound healing.Signaling network prediction by the Ontology Fingerprint enhanced Bayesian network.The WNKs: atypical protein kinases with pleiotropic actions.Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction

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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

http://www.wikidata.org/entity/Q28611364

description

2002 nî lūn-bûn

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2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年论文

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name

Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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type

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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prefLabel

Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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MCB.22.17.6023-6033.2002

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Molecular and Cellular Biology

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Rac-PAK signaling stimulates e ...... ormation of MEK1-ERK complexes

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P2093

Andrew D Catling

http://www.w3.org/2001/XMLSchema#string

Jill K Slack

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Michael J Weber

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Scott T Eblen

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P2860

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

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6023-6033

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scholarly article

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3219310

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10.1128/MCB.22.17.6023-6033.2002

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17

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22

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2002-09-01T00:00:00Z

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12167697

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134005

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