Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation
about
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptorMechanism of activation for Zap-70 catalytic activityThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationThe direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathwaysRegulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinaseSyk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptorThe serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transductionDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionIn vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylationRole of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signalingActivation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.B lymphocyte antigen receptor signaling: initiation, amplification, and regulationManagement of chronic lymphocytic leukemia (CLL) in the era of B-cell receptor signal transduction inhibitorsMolecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinaseAssociation of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alphaSyk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cellsRelocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with FakPhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionAnalysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesSyk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsReconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinasePhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyCharacterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cellsDownstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorDAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseReconstitution of the B cell antigen receptor signaling components in COS cellsThe Syk family of protein tyrosine kinases in T-cell activation and developmentPhysical and functional interactions between Lyn and p34cdc2 kinases in irradiated human B-cell precursors.Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor.Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3B cell antigen receptor signaling and internalization are mutually exclusive events.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.Negative signaling in health and disease.Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophilsB-cell receptor signaling as a driver of lymphoma development and evolution.
P2860
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P2860
Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation
description
1995 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1995
@ast
im Mai 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/05/12)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/05/12)
@nl
наукова стаття, опублікована в травні 1995
@uk
name
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@ast
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@en
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@nl
type
label
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@ast
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@en
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@nl
prefLabel
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@ast
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@en
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@nl
P2093
P356
P1476
Syk protein-tyrosine kinase is ...... inding and autophosphorylation
@en
P2093
A. L. Burkhardt
G. R. Matsueda
H. G. Chao
J. B. Bolen
R. B. Rowley
P304
11590–11594
P356
10.1074/JBC.270.19.11590
P407
P577
1995-05-12T00:00:00Z