Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
about
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motifCellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteinsA mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityIn vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.PIKfyve: Partners, significance, debates and paradoxesLoss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significanceInositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseasePhosphoinositides: tiny lipids with giant impact on cell regulationOsmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyveThe phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradationPIKfyve negatively regulates exocytosis in neurosecretory cellsLocalization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytesThe Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologistsType I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment.Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.Distinct pathogenic processes between Fig4-deficient motor and sensory neurons.Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage.Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C.Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondiiExploring phosphatidylinositol 5-phosphate 4-kinase function.PtdIns5P: news and views of its appearance, disappearance and deeds.Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiaeMechanism of substrate specificity of phosphatidylinositol phosphate kinases.Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults.Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress
P2860
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P2860
Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
description
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im November 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/11/26)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/11/26)
@nl
наукова стаття, опублікована в листопаді 1999
@uk
name
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@ast
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@en
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@nl
type
label
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@ast
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@en
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@nl
prefLabel
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@ast
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@en
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@nl
P2093
P2860
P356
P1476
Complementation analysis in Pt ...... inositol 3-phosphate 5-kinases
@en
P2093
A B Holmes
A Shisheva
G F Painter
R K McEwen
P2860
P304
33905-33912
P356
10.1074/JBC.274.48.33905
P407
P577
1999-11-01T00:00:00Z