Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway - Wikidata - awgldk - TriplyDB

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

http://www.wikidata.org/entity/Q28776004

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein The Mdm2 oncoprotein interacts with the cell fate regulator Numb Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate Mdm2: the ups and downs.The E7 oncoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF).The regulation of the p53-mediated stress response by MDM2 and MDM4.Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress.The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint.Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.The MDM2 gene family.Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing.The process of leukemogenesis A functional p53-responsive intronic promoter is contained within the human mdm2 gene.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation Cell type-specific inhibition of p53-mediated apoptosis by mdm2.Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription.Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment.Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor Osteosarcoma development and stem cell differentiation MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner.Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells.Regulation of the life cycle of HPVs by differentiation and the DNA damage response Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms.Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.ZGDHu-1 induces G₂/M phase arrest and apoptosis in Kasumi-1 cells.Zinc status alters growth and oxidative stress responses in rat hepatoma cells.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis.

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P2860

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

http://www.wikidata.org/entity/Q28776004

description

1994 nî lūn-bûn

@nan

1994 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի մարտին հրատարակված գիտական հոդված

@hy

1994年の論文

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1994年論文

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1994年論文

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1994年論文

@zh-hk

1994年論文

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1994年論文

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1994年论文

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name

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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type

label

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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prefLabel

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

@ast

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

@en

P2093

A J Fornace

http://www.w3.org/2001/XMLSchema#string

C Y Chen

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J D Oliner

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M B Kastan

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Q Zhan

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P2860

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

p53 mutations in human cancers

The p53-mdm-2 autoregulatory feedback loop

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Cancer. p53, guardian of the genome

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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2684-8

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scholarly article

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4923583

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10.1073/PNAS.91.7.2684

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7

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91

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Bert Vogelstein

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1994-03-29T00:00:00Z

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15053431

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8146175

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43434

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