Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.
about
Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionThe DNA damage response induced by infection with human cytomegalovirus and other virusesp53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirusHuman cytomegalovirus and human herpesvirus 6 genes that transform and transactivateEffects of human cytomegalovirus major immediate-early proteins in controlling the cell cycle and inhibiting apoptosis: studies with ts13 cellsInhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1.The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.Role of human cytomegalovirus immediate-early proteins in cell growth control.Herpesvirus lytic replication and the cell cycle: arresting new developmentsEffect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis.Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein.Role of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth.Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirusActinomycin D induces high-level resistance to thymidine analogs in replication of human immunodeficiency virus type 1 by interfering with host cell thymidine kinase expression.Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradationInhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.Specific chromosome 1 breaks induced by human cytomegalovirus.Identification of herpesvirus proteins that contribute to G1/S arrest.Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 proteinCyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.Functional interactions between herpesvirus oncoprotein MEQ and cell cycle regulator CDK2.Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).Degradation of p21cip1 in cells productively infected with human cytomegalovirus.Characterization of a human cytomegalovirus with phosphorylation site mutations in the immediate-early 2 protein.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.Potential role for p53 in the permissive life cycle of human cytomegalovirus.Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virionSmall internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86.
P2860
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P2860
Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@ast
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@en
type
label
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@ast
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@en
prefLabel
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@ast
Human cytomegalovirus IE2 86-k ...... rogate G1 checkpoint function.
@en
P2860
P1433
P1476
Human cytomegalovirus IE2 86-k ...... brogate G1 checkpoint function
@en
P2093
J K McDougall
P2860
P304
P407
P577
1997-08-01T00:00:00Z