Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors.
about
Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factorChronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytesInsulin enhances growth hormone induction of the MEK/ERK signaling pathwayc-Raf-mediated inhibition of epidermal growth factor-stimulated cell migration.Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activationPrenylation differentially inhibits insulin-dependent immediate early gene mRNA expression.PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by ErkDifferent pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinaseRole of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization.Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors.Insulin reverses growth hormone-induced homologous desensitization.Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex
P2860
Q28290100-185E62BD-F374-4500-B4E7-705C13970E42Q28364553-AF700DA9-623D-4801-AC8A-DC9D75B68FBCQ28576472-4902648B-1630-4B31-BD3F-53A4BC12B1ECQ30304264-A02CE4BE-589E-4C2C-900F-5107CE5C21CFQ34029480-D6CFD978-4C8C-4BA4-9494-8C12DE2C221CQ35992005-98DAC360-2B60-4C02-B419-CD9A217E9EC3Q37133085-6241B6ED-7A10-4A3A-85BA-6804FBCB04BBQ42526749-8661A67F-BE20-4697-B63F-9319C077E244Q42631549-11BA4C3A-D179-496D-BA7C-C621C7D382CCQ42811065-FDD8E471-699E-43D2-A7F0-77799AABE288Q45133871-B0F4DE83-EE28-491C-AC5E-25C335E6EDDAQ53621632-CB8E3CC4-8A63-4458-A710-68B0B7918238Q58197216-E2FDE3D3-1964-4E28-8030-751339EDE72E
P2860
Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors.
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Divergent mechanisms for homol ...... by insulin and growth factors.
@ast
Divergent mechanisms for homol ...... by insulin and growth factors.
@en
type
label
Divergent mechanisms for homol ...... by insulin and growth factors.
@ast
Divergent mechanisms for homol ...... by insulin and growth factors.
@en
prefLabel
Divergent mechanisms for homol ...... by insulin and growth factors.
@ast
Divergent mechanisms for homol ...... by insulin and growth factors.
@en
P2093
P2860
P356
P1476
Divergent mechanisms for homol ...... by insulin and growth factors.
@en
P2093
Cherniack AD
Klarlund JK
P2860
P304
23421-23428
P356
10.1074/JBC.270.40.23421
P407
P577
1995-10-01T00:00:00Z