The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseFYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cellsEvidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingShared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegansSerine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motifMolecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytesThe role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblGrowth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signalingInteraction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signalingThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagementPhosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicityRAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytesGrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesRegulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cellsThe involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activationThe adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interactionThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifRegulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsCoordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinasesT cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activationGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionA novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cellsCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323Identification of a novel 135-kDa Grb2-binding protein in osteoclastsCharacterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cellsPhosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinaseFyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsp120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinaseFyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsSyk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinaseInteractions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells.
P2860
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P2860
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@ast
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@en
type
label
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@ast
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@en
prefLabel
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@ast
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@en
P2093
P2860
P356
P1476
The SH3 domain-binding T cell ...... phosphatidylinositol 3-kinase.
@en
P2093
G Panchamoorthy
K A Reedquist
S E Shoelson
T Fukazawa
P2860
P304
19141-19150
P356
10.1074/JBC.270.32.19141
P407
P577
1995-08-01T00:00:00Z