Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). - Wikidata - awgldk - TriplyDB

Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).

Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).

http://www.wikidata.org/entity/Q30431323

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Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B Kinetochore-microtubule interactions: steps towards bi-orientation The kinetochore interaction network (KIN) of ascomycetes The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation KNL1: bringing order to the kinetochore Reconstituting the kinetochore–microtubule interface: what, why, and how Visualizing kinetochore architecture Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior.The Ndc80 kinetochore complex forms oligomeric arrays along microtubules A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores.Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae.Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.Multimodal microtubule binding by the Ndc80 kinetochore complex.Looping in on Ndc80 - how does a protein loop at the kinetochore control chromosome segregation?The Ndc80 complex: integrating the kinetochore's many movements.The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion.Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis The Ndc80 kinetochore complex directly modulates microtubule dynamics.Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions.Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation.Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity.Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Towards building a chromosome segregation machine.Contrasting models for kinetochore microtubule attachment in mammalian cells The life and miracles of kinetochores.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment.Sensing centromere tension: Aurora B and the regulation of kinetochore function.

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P2860

Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).

http://www.wikidata.org/entity/Q30431323

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

@ast

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

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type

label

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

@ast

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

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prefLabel

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

@ast

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

@en

P1433

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P356

J.CUB.2008.11.007

P1433

Current Biology

P1476

Kinetochore attachments requir ...... microtubules and Ndc80(Hec1).

@en

P2093

Michael L Johnson

http://www.w3.org/2001/XMLSchema#string

Stephanie A Miller

http://www.w3.org/2001/XMLSchema#string

P2860

The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation

The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.

hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment

Molecular organization of the Ndc80 complex, an essential kinetochore component.

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

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1785-1791

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scholarly article

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10.1016/J.CUB.2008.11.007

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22

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18

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P Todd Stukenberg

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2008-11-01T00:00:00Z

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23490455

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19026542

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P932

3145211

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