Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. - Wikidata - awgldk - TriplyDB

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.

http://www.wikidata.org/entity/Q30442556

about

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy mTOR signaling in growth control and disease mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice mTOR-dependent cell survival mechanisms Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1 mTOR signaling in tumorigenesis The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of -Adrenergic Receptor Signaling The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle.Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2 Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.mTOR complex 2 in adipose tissue negatively controls whole-body growth Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells.mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.mTOR complex 2 signaling and functions The effect of exercise on expression of myokine and angiogenesis mRNA in skeletal muscle of high fat diet induced obese rat.Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis.NOX4 pathway as a source of selective insulin resistance and responsiveness Mammalian target of rapamycin signaling in diabetic cardiovascular disease Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis.Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.

P2860

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P2860

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.

http://www.wikidata.org/entity/Q30442556

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Muscle-specific deletion of ri ...... al glycogen synthase activity.

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Muscle-specific deletion of ri ...... al glycogen synthase activity.

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type

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Muscle-specific deletion of ri ...... al glycogen synthase activity.

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prefLabel

Muscle-specific deletion of ri ...... al glycogen synthase activity.

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Muscle-specific deletion of ri ...... al glycogen synthase activity.

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P1433

Molecular and Cellular Biology

P1476

Muscle-specific deletion of ri ...... al glycogen synthase activity.

@en

P2093

Anil Kumar

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John C Lawrence

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Kin M Choi

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Susanna R Keller

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Thurl E Harris

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P2860

Glycogen and its Metabolism

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Mechanism of activation of protein kinase B by insulin and IGF-1

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

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61-70

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10.1128/MCB.01405-07

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1

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28

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17967879

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2223287

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