Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium
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TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemiaThe in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUGTemperature sensitivity of two-pore (K2P) potassium channelsA splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channelsSUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contractionN-terminal proteomics and ribosome profiling provide a comprehensive view of the alternative translation initiation landscape in mice and menLocalization and expression of CaBP1/caldendrin in the mouse brain.Cerebrovascular responses in mice deficient in the potassium channel, TREK-1.Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural modelsMolecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.Carvedilol targets human K2P 3.1 (TASK1) K+ leak channelsDifferential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.Molecular regulations governing TREK and TRAAK channel functions.Altered and dynamic ion selectivity of K+ channels in cell development and excitabilityTASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylationPharmacogenetic diversification by alternative translation initiation: background channels to the fore.PKC-dependent activation of human K(2P) 18.1 K(+) channels.Variants of stretch-activated two-pore potassium channel TREK-1 associated with preterm labor in humans.Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities.Positional proteomics reveals differences in N-terminal proteoform stability.Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.Deep proteome coverage based on ribosome profiling aids mass spectrometry-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation eventsFormation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.The purified mechanosensitive channel TREK-1 is directly sensitive to membrane tension.Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics.N-terminal isoforms of the large-conductance Ca²⁺-activated K⁺ channel are differentially modulated by the auxiliary β1-subunit.Ion channels under the sun.T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter.Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging themeSodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.A Role for K2P Channels in the Operation of Somatosensory NociceptorsThe proteome under translational control.Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.The family of K2P channels: salient structural and functional properties.Much more than a leak: structure and function of K₂p-channels.
P2860
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P2860
Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Alternative translation initia ...... m channels permeable to sodium
@ast
Alternative translation initia ...... m channels permeable to sodium
@en
type
label
Alternative translation initia ...... m channels permeable to sodium
@ast
Alternative translation initia ...... m channels permeable to sodium
@en
prefLabel
Alternative translation initia ...... m channels permeable to sodium
@ast
Alternative translation initia ...... m channels permeable to sodium
@en
P2093
P2860
P1433
P1476
Alternative translation initia ...... m channels permeable to sodium
@en
P2093
Christina M Wilkens
Dierk Thomas
Leigh D Plant
Zoe A McCrossan
P2860
P304
P356
10.1016/J.NEURON.2008.04.016
P407
P577
2008-06-01T00:00:00Z