Effects of overexpression of huntingtin proteins on mitochondrial integrity. - Wikidata - awgldk - TriplyDB

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

http://www.wikidata.org/entity/Q30489322

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Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies Defining the role of the Bcl-2 family proteins in Huntington's disease Mitochondrial morphology-emerging role in bioenergetics The dynamics of the mitochondrial organelle as a potential therapeutic target Calcium channel blockers and Alzheimer's disease Mitochondrial quality control: decommissioning power plants in neurodegenerative diseases Novel mitochondrial targets for neuroprotection Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration Mechanisms of aging-related proteinopathies in Caenorhabditis elegans The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases Shaping the role of mitochondria in the pathogenesis of Huntington's disease Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis Impaired balance of mitochondrial fission and fusion in Alzheimer's disease Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases S-glutathionylation: from molecular mechanisms to health outcomes Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Metabolic profiling for the identification of Huntington biomarkers by on-line solid-phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools.Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.Potential therapeutic benefits of strategies directed to mitochondria.Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission Therapeutic approaches to preventing cell death in Huntington disease Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions Direct reprogramming of Huntington's disease patient fibroblasts into neuron-like cells leads to abnormal neurite outgrowth, increased cell death, and aggregate formation Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.Effect of erythropoietin on the expression of dynamin-related protein-1 in rat renal interstitial fibrosis.Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases.A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles

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P2860

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

http://www.wikidata.org/entity/Q30489322

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

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2008年論文

@zh-tw

2008年论文

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name

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

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Effects of overexpression of huntingtin proteins on mitochondrial integrity.

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type

label

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

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Effects of overexpression of huntingtin proteins on mitochondrial integrity.

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prefLabel

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

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Effects of overexpression of huntingtin proteins on mitochondrial integrity.

@en

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Human Molecular Genetics

P1476

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

@en

P2093

Hongmin Wang

http://www.w3.org/2001/XMLSchema#string

Mariusz Karbowski

http://www.w3.org/2001/XMLSchema#string

Mervyn J Monteiro

http://www.w3.org/2001/XMLSchema#string

Precious J Lim

http://www.w3.org/2001/XMLSchema#string

P2860

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

The genetics of Caenorhabditis elegans

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

Huntingtin aggregation and toxicity in Huntington's disease

Mitochondria: dynamic organelles in disease, aging, and development

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

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737-752

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10.1093/HMG/DDN404

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4

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18

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2008-11-27T00:00:00Z

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23502806

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19039036

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2722218

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