Identification of the minimal tyrosine residues required for linker for activation of T cell function.
about
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionSynergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domainsRecruitment and activation of PLCgamma1 in T cells: a new insight into old domainsThe importance of three membrane-distal tyrosines in the adaptor protein NTAL/LABThe tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signalingThe polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarizationScaffold proteins: hubs for controlling the flow of cellular informationDual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceGPVI and integrin alphaIIb beta3 signaling in plateletsHematopoietic adaptors in T-cell signaling: potential applications to transplantationStructural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Persistence of cooperatively stabilized signaling clusters drives T-cell activationSingle-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clusteringPhosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clustersEarly phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.Examining multiprotein signaling complexes from all anglesPositive and negative regulation of T-cell activation by adaptor proteins.Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.Itk: the rheostat of the T cell response.Adaptors as central mediators of signal transduction in immune cells.The role of Tec family kinases in T cell development and function.Transmembrane adapters: attractants for cytoplasmic effectors.Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation.Endocytic events in TCR signaling: focus on adapters in microclustersLck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.Positive and negative adaptors in T-cell signalling.Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.Transmembrane adaptor proteins: organizers of immunoreceptor signalling.The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclustersCondensation of the plasma membrane at the site of T lymphocyte activationDifferential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapterThe role of the LAT-PLC-gamma1 interaction in T regulatory cell function.A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunityCompartmentalization of ITAM and integrin signaling by adapter molecules.
P2860
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P2860
Identification of the minimal tyrosine residues required for linker for activation of T cell function.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Identification of the minimal ...... activation of T cell function.
@en
Identification of the minimal ...... activation of T cell function.
@nl
type
label
Identification of the minimal ...... activation of T cell function.
@en
Identification of the minimal ...... activation of T cell function.
@nl
prefLabel
Identification of the minimal ...... activation of T cell function.
@en
Identification of the minimal ...... activation of T cell function.
@nl
P2860
P356
P1476
Identification of the minimal ...... activation of T cell function.
@en
P2860
P304
29588-29595
P356
10.1074/JBC.M102221200
P407
P577
2001-06-06T00:00:00Z