Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinQuantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseThe secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationIdentification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsThe proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levelsAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer diseaseFurin at the cutting edge: from protein traffic to embryogenesis and diseaseAmyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid raftsPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHTrafficking regulation of proteins in Alzheimer's diseaseRole of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipaseThe secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesisTrafficking and proteolytic processing of APPSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsHepatic proprotein convertases modulate HDL metabolismImplication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous systemThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Altered palmitoylation and neuropathological deficits in mice lacking HIP14.Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat.Prodomain processing of Asp1 (BACE2) is autocatalytic.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Beta-secretase: structure, function, and evolution.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseΒ-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional studyInhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor proteinProprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.Beta-secretase as a target for the treatment of Alzheimer's disease.Beta-secretase activity increases with aging in human, monkey, and mouse brain.Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model.
P2860
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P2860
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Post-translational processing ...... y and amyloid-beta production.
@ast
Post-translational processing ...... y and amyloid-beta production.
@en
type
label
Post-translational processing ...... y and amyloid-beta production.
@ast
Post-translational processing ...... y and amyloid-beta production.
@en
prefLabel
Post-translational processing ...... y and amyloid-beta production.
@ast
Post-translational processing ...... y and amyloid-beta production.
@en
P2093
P356
P1476
Post-translational processing ...... y and amyloid-beta production.
@en
P2093
Benjannet S
Chrétien M
Cromlish JA
Mamarbachi M
P304
10879-10887
P356
10.1074/JBC.M009899200
P407
P577
2001-01-10T00:00:00Z