A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
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Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling PathwaysMechanisms of cellular invasion by intracellular parasitesIdentification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziSchistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitorComputational identification of uncharacterized cruzain binding sitesFunctional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interferenceCure of hookworm infection with a cysteine protease inhibitorIdentification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPBScaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitorsQuantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseIdentification of a new class of nonpeptidic inhibitors of cruzain.Two approaches to discovering and developing new drugs for Chagas disease.Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunityProtease inhibitors targeting coronavirus and filovirus entryClinical aspects of Chagas disease and implications for novel therapies.Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Epidemiology and Molecular Typing of Trypanosoma cruzi in Naturally-Infected Hound Dogs and Associated Triatomine Vectors in Texas, USASynthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Innovative lead discovery strategies for tropical diseases.Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.Chagas' disease: an update on immune mechanisms and therapeutic strategiesDevelopment of protease inhibitors for protozoan infections.Reversible cysteine protease inhibitors show promise for a Chagas disease cure.Advances and challenges towards a vaccine against Chagas disease.Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.Recent initiatives and strategies to developing new drugs for tropical parasitic diseases.Potential new clinical therapies for Chagas disease.Therapeutical approaches under investigation for treatment of Chagas disease.Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Targeting proteasomes in infectious organisms to combat disease.α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease.Experimental and Clinical Treatment of Chagas Disease: A Review.Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β ActivationTetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease
P2860
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P2860
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@ast
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@en
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@nl
type
label
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@ast
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@en
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@nl
prefLabel
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@ast
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@en
A cysteine protease inhibitor ...... nfection by Trypanosoma cruzi.
@nl
P2093
P2860
P1476
A cysteine protease inhibitor ...... infection by Trypanosoma cruzi
@en
P2093
B G Kornreic
J H McKerrow
J Piscitelli
K L Warner
P2860
P304
P356
10.1128/AAC.49.12.5160-5161.2005
P407
P50
P577
2005-12-01T00:00:00Z