The chemistry and biology of the bryostatin antitumour macrolides.
about
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationTotal synthesis of bryostatin 16 using atom-economical and chemoselective approachesA eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragmentsDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroIdentifying bryostatins and potential precursors from the bryozoan Bugula neritina.Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Mechanism targeted discovery of antitumor marine natural products.Bryostatins: biological context and biotechnological prospects.Total synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Translating Nature's Library: The Bryostatins and Function-Oriented SynthesisTotal synthesis of bryostatin 1Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation.Synthetic studies on the bryostatins: synthetic routes to analogues containing the tricyclic macrolactone coreEnantio- and diastereoselective additions to aldehydes using the bifunctional reagent 2-(chloromethyl)-3-(tributylstannyl)propene: application to a synthesis of the C16-C27 segment of bryostatin 1Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsLead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyNeristatin 1 provides critical insight into bryostatin 1 structure-function relationshipsConformation-activity relationships of polyketide natural products.Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ringMycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylationMarine-derived angiogenesis inhibitors for cancer therapy."Candidatus Endobugula glebosa," a specific bacterial symbiont of the marine bryozoan Bugula simplexStrategies for the synthesis of the novel antitumor agent peloruside A.The medicinal potential of promising marine macrolides with anticancer activity.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products.Hydrogen-Atom Transfer Reactions.The advancement of multidimensional QSAR for novel drug discovery - where are we headed?Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
P2860
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P2860
The chemistry and biology of the bryostatin antitumour macrolides.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The chemistry and biology of the bryostatin antitumour macrolides.
@ast
The chemistry and biology of the bryostatin antitumour macrolides.
@en
The chemistry and biology of the bryostatin antitumour macrolides.
@nl
type
label
The chemistry and biology of the bryostatin antitumour macrolides.
@ast
The chemistry and biology of the bryostatin antitumour macrolides.
@en
The chemistry and biology of the bryostatin antitumour macrolides.
@nl
prefLabel
The chemistry and biology of the bryostatin antitumour macrolides.
@ast
The chemistry and biology of the bryostatin antitumour macrolides.
@en
The chemistry and biology of the bryostatin antitumour macrolides.
@nl
P2093
P356
P1476
The chemistry and biology of the bryostatin antitumour macrolides.
@en
P2093
Karl J Hale
Marc G Hummersone
Mark Frigerio
Soraya Manaviazar
P304
P356
10.1039/B009211H
P577
2002-08-01T00:00:00Z