Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
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WNT-3a modulates platelet function by regulating small GTPase activityNormal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)The small GTPase Rif is dispensable for platelet filopodia generation in miceA novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.Signaling role of Cdc42 in regulating mammalian physiology.Proteomic analysis of palmitoylated platelet proteinsThe adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signalingPlatelet-neutrophil interactions under thromboinflammatory conditionsVAMP-7 links granule exocytosis to actin reorganization during platelet activation.The PAK system links Rho GTPase signaling to thrombin-mediated platelet activationRhoG protein regulates platelet granule secretion and thrombus formation in mice.Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.Platelet signaling-a primer.Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.Rho GTPases in platelet functionSecrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?Platelet Rho GTPases-a focus on novel players, roles and relationships.Integrin αIIbβ3 outside-in signaling.Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability.Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.Signalling Pathways Controlling Cellular Actin Organization.Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response.Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach.The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi.Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.Effect of supplementation with an 80:20cis9,trans11 conjugated linoleic acid blend on the human platelet proteomeFurther evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.
P2860
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P2860
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@ast
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@en
type
label
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@ast
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@en
prefLabel
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@ast
Multiple alterations of platel ...... ce lacking Cdc42 in platelets.
@en
P2093
P50
P1433
P1476
Multiple alterations of platel ...... ice lacking Cdc42 in platelets
@en
P2093
Bernhard Nieswandt
Christian Gachet
Ina Hagedorn
Irina Pleines
Margitta Elvers
Markus Bender
Sandra Eliautou
P304
P356
10.1182/BLOOD-2009-09-242271
P407
P577
2010-02-04T00:00:00Z