Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. - Wikidata - awgldk - TriplyDB

Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

http://www.wikidata.org/entity/Q33395224

about

MicroRNAs in NF-kappaB signaling Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma Inflammation meets cancer, with NF-κB as the matchmaker Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha.Mouse models of cancer as biological filters for complex genomic data.Oncogenic activation of NF-kappaB.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.Using functional genomics to overcome therapeutic resistance in hematological malignancies.Rapid Identification of Therapeutic Targets in Hematologic Malignancies via Functional Genomics.BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression.Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21.Systems biology in immunology: a computational modeling perspective.B-cell receptor signaling in diffuse large B-cell lymphoma.NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma.EBV LMP1: New and shared pathways to NF-κB activation.Genome-wide siRNA screen for mediators of NF-κB activation Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines.Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.NF-kappaB signaling: multiple angles to target OA.The kinase NIK as a therapeutic target in multiple myeloma.Towards systematic functional characterization of cancer genomes.NF-κB and the link between inflammation and cancer.NF-κB signaling pathways: role in nervous system physiology and pathology.III. Applying molecular phenotyping in practice.Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies.Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.RNAi Screening of Leukemia Cells Using Electroporation Bioluminescence Imaging to Monitor the Effects of the Hsp90 Inhibitor NVP-AUY922 on NF-κB Pathway in Endometrial Cancer.

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Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

http://www.wikidata.org/entity/Q33395224

description

2008 nî lūn-bûn

@nan

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Compensatory IKKalpha activati ...... rference sensitization screen.

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Compensatory IKKalpha activati ...... rference sensitization screen.

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type

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Compensatory IKKalpha activati ...... rference sensitization screen.

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Compensatory IKKalpha activati ...... rference sensitization screen.

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Compensatory IKKalpha activati ...... rference sensitization screen.

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Compensatory IKKalpha activati ...... rference sensitization screen.

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PNAS.0806491106

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Proceedings of the National Academy of Sciences of the United States of America

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Compensatory IKKalpha activati ...... rference sensitization screen.

@en

P2093

Georg Lenz

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George Wright

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Hong Zhao

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Lenny Dang

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Lloyd T Lam

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Louis M Staudt

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R Eric Davis

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Vu N Ngo

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Weihong Xu

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Xin Yu

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P2860

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Phosphorylation of the CARMA1 linker controls NF-kappaB activation

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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20798-20803

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10.1073/PNAS.0806491106

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105

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23685646

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19104039

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2634958

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