E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. - Wikidata - awgldk - TriplyDB

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

http://www.wikidata.org/entity/Q33673921

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Biochemical profiling of histone binding selectivity of the yeast bromodomain family Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 The mechanisms behind the therapeutic activity of BET bromodomain inhibition BET domain co-regulators in obesity, inflammation and cancer A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.Brd2 disruption in mice causes severe obesity without Type 2 diabetes.Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines.Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential Parallel imaging microfluidic cytometer.Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder.An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.BET bromodomain inhibitors: a patent review.Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy L2pB1: a new player in autoimmunity.BET bromodomain proteins are required for glioblastoma cell proliferation.Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest.Murine models of B-cell lymphomas: promising tools for designing cancer therapies Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell.'Metabolically healthy obesity': origins and implications.Fas apoptosis inhibitory molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease.Structure and acetyl-lysine recognition of the bromodomain.Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters.Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma.The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse Clinical trials for BET inhibitors run ahead of the science.The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions.Bromodomains and their pharmacological inhibitors.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.

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E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

http://www.wikidata.org/entity/Q33673921

description

2003 nî lūn-bûn

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2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

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E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

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type

label

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

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E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

@en

prefLabel

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

@ast

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

@en

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E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia

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Anupama Sinha

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Douglas V Faller

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Joseph R Tumang

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Nicolas Currier

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Rebecca J Greenwald

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Robert D Cardiff

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Thomas L Rothstein

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P2860

Structure and ligand of a histone acetyltransferase bromodomain

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

E2F transcriptional activation requires TRRAP and GCN5 cofactors

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F

The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

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10.1182/BLOOD-2003-06-2116

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