AML1 deletion in adult mice causes splenomegaly and lymphomas.
about
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory elementThe contribution of mouse models to the understanding of constitutional thrombocytopeniaIsoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignanciesTranscriptional control of megakaryocyte development.PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisThrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1.Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cellsRunx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.A flow cytometric assay to quantify invasion of red blood cells by rodent Plasmodium parasites in vivoPractical murine hematopathology: a comparative review and implications for research.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingTranscriptional Auto-Regulation of RUNX1 P1 Promoter.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeNormal and malignant megakaryopoiesis.Erythroid and megakaryocytic transformation.FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.A regulatory interplay between miR-27a and Runx1 during megakaryopoiesisLeukemia and hematopoietic stem cells: balancing proliferation and quiescence.Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasisEssential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomasEarly chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.Shwachman-Diamond syndrome: implications for understanding the molecular basis of leukaemia.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiationCore binding factor at the crossroads: determining the fate of the HSC.Hematopoietic stem cell emergence in the conceptus and the role of Runx1.Mouse models of diseases of megakaryocyte and platelet homeostasis.microRNA regulation in megakaryocytopoiesis.B-lineage transcription factors and cooperating gene lesions required for leukemia development.RUNX1: A microRNA hub in normal and malignant hematopoiesis.A role for RUNX1 in hematopoiesis and myeloid leukemia.A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cellsThe RUNX1-PU.1 axis in the control of hematopoiesis.Mouse models for core binding factor leukemia.
P2860
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P2860
AML1 deletion in adult mice causes splenomegaly and lymphomas.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@ast
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@en
type
label
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@ast
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@en
prefLabel
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@ast
AML1 deletion in adult mice causes splenomegaly and lymphomas.
@en
P2093
P356
P1433
P1476
AML1 deletion in adult mice causes splenomegaly and lymphomas
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1209136
P407
P577
2006-02-01T00:00:00Z
P5875
P6179
1018233363