Functional analysis of coordinated cleavage in V(D)J recombination.
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Amino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processThe RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinaseCompound heterozygous mutation of Rag1 leading to Omenn syndromeCrystal structure of the V(D)J recombinase RAG1-RAG2Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingDistinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthA RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationIrradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesRAG transposase can capture and commit to target DNA before or after donor cleavageOrdered assembly of the V(D)J synaptic complex ensures accurate recombinationThe RAG proteins in V(D)J recombination: more than just a nuclease.Assembly of the RAG1/RAG2 synaptic complexThe C-terminal portion of RAG2 protects against transposition in vitroBase flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksMutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.Requirements for DNA hairpin formation by RAG1/2The molecular basis and biological significance of VH replacement.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoireEffect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavage.Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes.A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination.RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule.Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule.The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire.
P2860
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P2860
Functional analysis of coordinated cleavage in V(D)J recombination.
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Functional analysis of coordinated cleavage in V(D)J recombination.
@ast
Functional analysis of coordinated cleavage in V(D)J recombination.
@en
type
label
Functional analysis of coordinated cleavage in V(D)J recombination.
@ast
Functional analysis of coordinated cleavage in V(D)J recombination.
@en
prefLabel
Functional analysis of coordinated cleavage in V(D)J recombination.
@ast
Functional analysis of coordinated cleavage in V(D)J recombination.
@en
P2860
P356
P1476
Functional analysis of coordinated cleavage in V(D)J recombination.
@en
P2093
M A Oettinger
P2860
P304
P356
10.1128/MCB.18.8.4679
P407
P577
1998-08-01T00:00:00Z