Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
about
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposonsAmino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processA functional analysis of the spacer of V(D)J recombination signal sequencesStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1The taming of a transposon: V(D)J recombination and the immune systemDeterminants for hairpin formation in Tn10 transposition.Embryonic expression and regulation of the large zinc finger protein KRCSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent.Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.Evolution of immunoglobulin and T-cell receptor gene assembly.Functional analysis of coordinated cleavage in V(D)J recombination.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthRAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Postcleavage sequence specificity in V(D)J recombination.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesThe DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesRAG transposase can capture and commit to target DNA before or after donor cleavageOrdered assembly of the V(D)J synaptic complex ensures accurate recombinationThe RAG proteins in V(D)J recombination: more than just a nuclease.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseAssembly of the RAG1/RAG2 synaptic complexRAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksOverlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.The bounty of RAGs: recombination signal complexes and reaction outcomes.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesUnderstanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.
P2860
Q21092810-5C2922DB-98EA-4799-B6ED-7E19DE055C69Q24301696-92F8599D-7AF1-48C4-A593-83848B16D65FQ24803713-1BB1DBB8-E9FC-4543-B2D4-0B72E7272B29Q27655283-840F35F8-3185-4AB5-8F69-FC630DACA81FQ28270912-B51C2F39-AD79-42EF-A4BB-2D960487F0E2Q28270945-5ADD805F-D12A-4DA4-8258-86DE728527C2Q28366147-3E7E1272-8EC0-449C-A87E-05A71122DBB9Q28591133-2BA23ECC-FB5D-487C-AAAA-1C5D8077E9D5Q31136147-A848909D-1451-4C45-A5F4-F1E4C7115899Q33326487-872E349B-BC11-4AFA-8679-A84A9015AF33Q33616848-B16624D2-0296-4B19-8DBC-6685DCAB36FBQ33692260-EEB71348-4D69-46B6-AC4B-3765DD89ACB1Q33775583-0702D6E7-BF67-4DFA-AD3F-89CEBAAF32F8Q33857055-FF8CB946-314E-4326-ABDF-27567A910A03Q33958065-EECECD7F-129D-460A-ABB4-4B7B8D453787Q33958242-425B9134-DE7B-46D6-8517-B33750B8B5B1Q33958478-BD4B05C6-E2F7-4E52-9D58-5D4D71ABBC2EQ33964568-3523CF6B-9E4E-48BA-8D7F-7DB095A116ADQ33964869-9C6C2D89-C504-4B67-BCFE-8F83C24C1A41Q33966875-AE8CBC5E-EA6D-4B89-8DC2-B019417E6D36Q33966887-E9509277-D012-4052-80FD-4D754BFD8739Q33967550-28FED6E9-252C-4306-81FA-AE2B23F52133Q33968434-7A7B853B-F019-46E4-9FB2-8690786BC271Q33968558-F7DDFFB5-308E-460C-8926-A908430B0367Q33968578-307CB131-2A2D-4388-A87C-75AA7C7295F5Q34090070-CAA61ECB-8FF2-415E-9047-F548C67B404DQ34194287-6F2CAFC5-96DC-4EF4-B2D9-8074A03911D4Q34279162-2831A442-B96E-434A-8861-85779FBDEC37Q34290414-479EDF3C-9651-428F-8477-74D939A17518Q34321067-A88C8681-4184-4510-B954-62BAB1B575B2Q35000484-10F92D2B-7EA5-4DD0-88B2-D96568138E19Q35161631-74AE73E4-F1C4-4AEF-B0E5-6C4F12153C5DQ35210006-A0EC7FCC-46B5-4E35-AB49-C81388CCA870Q35663928-E8A259DE-122D-4EEB-AA4B-476CF898EF71Q35830390-567CCA66-C276-410C-9FC8-686330FCAACEQ35830395-0893B3DB-643D-4981-8AE2-AFB5F2AC35BEQ35830402-55297D92-6519-46B4-8A88-517877AC6A73Q35830448-1411253F-1F6D-46CB-8EBF-B68C890C0FD7Q35860813-5F6EF9F3-D369-46EE-BC26-DF0C3FFA8B70Q36676457-E53A9959-CD6D-4658-92BB-DCD03D4D0103
P2860
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@ast
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@en
type
label
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@ast
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@en
prefLabel
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@ast
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@en
P2860
P356
P1476
Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.
@en
P2093
M A Oettinger
Y Akamatsu
P2860
P304
P356
10.1128/MCB.18.8.4670
P407
P577
1998-08-01T00:00:00Z