DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
about
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locusPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Determinants for hairpin formation in Tn10 transposition.Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinaseSequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutationsHMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences.Functional analysis of coordinated cleavage in V(D)J recombination.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro.Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleDetection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.The RAG proteins in V(D)J recombination: more than just a nuclease.Targeted transposition by the V(D)J recombinase.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseAssembly of the RAG1/RAG2 synaptic complexIntrinsic characteristics of neighboring DNA modulate transposable element activity in Drosophila melanogaster.Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage.The C-terminal portion of RAG2 protects against transposition in vitroBase flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksDrosophila P-element transposase is a novel site-specific endonuclease.Patterns of sequence conservation at termini of long terminal repeat (LTR) retrotransposons and DNA transposons in the human genome: lessons from phage Mu.Requirements for DNA hairpin formation by RAG1/2DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.The bounty of RAGs: recombination signal complexes and reaction outcomes.How to keep V(D)J recombination under control.V(H) replacement in rearranged immunoglobulin genes.Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.Cryptic signals and the fidelity of V(D)J joining.A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity.V(D)J recombination: in vitro coding joint formation.RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solutionUnderstanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.Unifying model for molecular determinants of the preselection Vβ repertoire.
P2860
Q24647015-7BF9950A-441B-4DE2-8A8E-5793C35878D8Q28270912-8029D43B-D948-4C58-AAEF-69001AE49AA8Q28366147-0B6B77A7-9767-488D-9AC5-3A7210C95E69Q28510756-5EAB1C12-C8D2-41F2-94EB-D97227D99A38Q33335911-82B21241-F483-4D8F-9E7F-293EE74C2BFCQ33421568-227368C2-E69C-4959-A9EA-5EE2FE8ECF23Q33775546-1055963A-35A6-4C61-A6EE-60BEB9618768Q33775583-461D6222-DD40-49C1-ADD6-327747508F35Q33871220-12D153E2-FA9D-4683-8609-D7F121B1271DQ33886625-E7BD6B54-EF9A-4343-9D6E-19010ABBD19FQ33888644-B5CA596E-CAEB-4569-B183-B26675C2DA5BQ33889351-94C4E8C9-5734-4D98-8396-85E7E61463F6Q33899849-F1606A8F-06E8-4E62-AF93-FF7F1791A57EQ33958242-CC6D8FFD-20C3-4779-A841-AADFB50BE020Q33960582-095BEDC4-B573-489A-9F6D-D52CE95C6184Q33966887-280FC821-7024-4ABF-BBAB-A0BEED85413FQ33967550-38C731F9-B828-4641-A7EA-CB475A0F9915Q34194287-79C1E956-83B5-4E8A-A901-CF06D0705D7EQ34276357-4133A310-1869-40FF-9FDE-77082F23CE6AQ34279162-B794EACA-054D-4BF4-B1E7-B0A3ABE86282Q34290414-4CA126F0-A6F4-4A49-8A24-4B6A95D6849CQ34477499-99C81159-616C-4766-AC6F-521696D791DEQ34641788-7A5A14EE-DEAE-4E2A-9EE1-B9682F73F614Q34985848-9590B438-4346-43AA-B7CF-1C4BF456D51FQ35000484-2441254C-9AD7-43A9-97AE-3CDD7C596993Q35188701-B697B542-9443-4B6E-B637-339600FAF4C8Q35222265-A8AA000C-42C4-4D9A-8C3C-B4C174976C9BQ35652497-2BB7938F-3AFB-4FF3-B848-7182B9932979Q35663928-4F8A606D-AA02-40E2-9092-F2AAEBBEE2B2Q35830402-5469D053-4A6E-4D6D-8062-1B4B75AB1015Q35830422-A8BBA718-F965-4220-9211-0BB338B2FB1FQ36018549-2A5DDBBB-F0C2-4C38-A37B-1AB728793304Q36404067-E277F96C-C71E-4436-AD89-3E29DA5AB9AEQ36568596-A4187473-8FA0-43F5-8B27-D5F947112E8AQ36570198-0637626D-3D33-4316-8BC8-C5B9C4700978Q36573432-09461905-0B51-4485-9F20-995D8BFC2CB5Q36573841-CEB2591B-4D21-45C0-B74A-A52301D40CF2Q36676457-EACA435A-E5B5-4C4F-8E07-7FD3CF39CF15Q37111606-DBF4FCD3-1601-4207-B887-0321E6E595A5Q37117734-A6007541-8A6B-4B72-8172-E41F252A39A9
P2860
DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
DNA sequence and structure req ...... recombination signal sequences
@ast
DNA sequence and structure req ...... recombination signal sequences
@en
type
label
DNA sequence and structure req ...... recombination signal sequences
@ast
DNA sequence and structure req ...... recombination signal sequences
@en
prefLabel
DNA sequence and structure req ...... recombination signal sequences
@ast
DNA sequence and structure req ...... recombination signal sequences
@en
P2860
P356
P1476
DNA sequence and structure req ...... recombination signal sequences
@en
P2093
M A Oettinger
P2860
P304
P356
10.1128/MCB.16.10.5683
P407
P577
1996-10-01T00:00:00Z