Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsThe mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4.The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.Brd4-independent transcriptional repression function of the papillomavirus e2 proteinsBrd4 links chromatin targeting to HPV transcriptional silencingAbrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repressionInduction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells.Papillomavirus interaction with cellular chromatin.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expressionRepression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition.Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligaseNCoR1 mediates papillomavirus E8;E2C transcriptional repressionTumourigenesis driven by the human papillomavirus type 16 Asian-American e6 variant in a three-dimensional keratinocyte modelAlleviation of human papillomavirus E2-mediated transcriptional repression via formation of a TATA binding protein (or TFIID)-TFIIB-RNA polymerase II-TFIIF preinitiation complex.E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expressionHuman TATA binding protein inhibits human papillomavirus type 11 DNA replication by antagonizing E1-E2 protein complex formation on the viral origin of replication.Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31.Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cellsE2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death.Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells.Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survivalReplication and partitioning of papillomavirus genomes.Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cellsPrimary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation.Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence.Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways.The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells.Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation.Mutations in the GM1 binding site of simian virus 40 VP1 alter receptor usage and cell tropism.Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapiesGuidelines of the Italian Society for Virology on HPV testing and vaccination for cervical cancer prevention.Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.The papillomavirus E2 proteinsRapid induction of senescence in human cervical carcinoma cells.Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.HPV16-E2 protein modifies self-renewal and differentiation rate in progenitor cells of human immortalized keratinocytes.
P2860
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P2860
Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Transactivation-competent bovi ...... cervical carcinoma cell lines
@ast
Transactivation-competent bovi ...... cervical carcinoma cell lines
@en
type
label
Transactivation-competent bovi ...... cervical carcinoma cell lines
@ast
Transactivation-competent bovi ...... cervical carcinoma cell lines
@en
prefLabel
Transactivation-competent bovi ...... cervical carcinoma cell lines
@ast
Transactivation-competent bovi ...... cervical carcinoma cell lines
@en
P2093
P2860
P1433
P1476
Transactivation-competent bovi ...... cervical carcinoma cell lines
@en
P2093
D E Breiding
E C Goodwin
E J Androphy
L K Naeger
P2860
P304
P577
1998-05-01T00:00:00Z