Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking. - Wikidata - awgldk - TriplyDB

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

http://www.wikidata.org/entity/Q33816664

about

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition Two-pore channels form homo- and heterodimers Hax-1 identified as a two-pore channel (TPC)-binding protein Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells Two-pore channels function in calcium regulation in sea star oocytes and embryos.Regulation of lysosomal ion homeostasis by channels and transporters Principles of Virus Uncoating: Cues and the Snooker Ball Two-pore channels at the intersection of endolysosomal membrane traffic High susceptibility to fatty liver disease in two-pore channel 2-deficient mice Domain assembly of NAADP-gated two-pore channels Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1 Linking NAADP to ion channel activity: a unifying hypothesis TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals Two-pore channels (TPCs): current controversies TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes.Two-Pore Channels and Parkinson's Disease: Where's the Link?Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases.TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP NAADP receptors.Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Structure and function of ER membrane contact sites with other organelles Two-Pore Channels: Lessons from Mutant Mouse Models Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.Organelle-specific subunit interactions of the vertebrate two-pore channel family.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

P2860

Q24293723-24C2A68E-5F79-4196-9602-DDE880ABE19F Q24307004-F4ED04C4-0523-4984-95B9-F1E56CA8C5C6 Q24337485-F2B9F715-32DD-4291-8E0D-8E600A1740D7 Q24339389-C63EA3D8-B197-43B9-B01B-24F75BD0BA47 Q24600390-51E24EB5-0086-4B2B-AF63-DC72E5ABCFE4 Q24600457-F79073A9-C68D-44A8-90F3-AEFFA6830035 Q24621022-2DE0ED40-6E75-45C6-91C5-9EFE5BD388FD Q27322498-727E11C9-F535-4873-A967-D24874962118 Q27346606-273250CB-CF53-4ABB-9653-DB5B39BDC6B0 Q28069327-0F0B20F8-D0F0-40B7-9999-7245FCD6EBE6 Q28074854-D1AC2042-5C2E-44F4-A150-A56D5B5B7512 Q28085768-1BC40A69-7144-428D-A295-E7507CA28AE2 Q28246421-7B32D59A-6DB0-4993-8A50-85472B9AB375 Q28250269-32A86DDC-91DE-47C8-8B53-7D7D8FD3697B Q28260464-C8BB9278-6DBD-433A-BDCF-EFC8ED663CFB Q28262391-4FE992E6-0B34-4A41-BBA0-A655178E790F Q28264441-D84047FE-38A4-409F-B6A4-215B5E168C11 Q28265293-EC20E915-E1EA-43A7-93C6-B3DE1B10C08D Q28276964-DB80A92A-4E04-46BF-B14A-D4DD1CFACDEA Q28286984-7705559F-AA09-4058-95AB-E6F90BCD2F1A Q28294394-5D687558-C583-4A06-A2E1-50D7337E50BC Q28302766-84D4CE23-F5EC-45AE-81E6-D76D4B8F9ED2 Q28588920-5AB034F2-0D82-4A33-831A-EBCAF0DDBFE9 Q30537817-A67C415F-8BF7-4434-BBCB-391C795A94EE Q33703425-5CB5C4F5-F039-4C3B-8692-ED81D68A0FC7 Q33755195-FDCEA0D0-E15D-4CEB-982E-E64F20973497 Q33840138-89DE8A61-F5C0-43B5-96DA-B2A497C786FB Q34147867-81A19AC3-DCC4-4FAB-9423-615A1BF3B85E Q34464824-D99DC446-DC60-4B88-BA94-9AFCB086C049 Q34483905-51569D0C-E1F5-4567-9CD2-A5D61E9C5E64 Q34483914-252CECD9-FBA0-42BA-8066-843F492E7E67 Q34503783-F61FD4A1-0874-4A24-B1E4-D8479996997A Q34531617-69BF5354-9493-454D-A771-053BEFEB7640 Q34551759-2A5F77C7-7824-481E-95A8-09F64E4A24CB Q34552502-6EA733C1-9659-4CDC-8BE7-0CDD6E4AD961 Q34583526-CC7B4D50-E704-4B4D-9C02-6F39785BF54A Q34685254-1572D1A9-7F57-415F-AC94-028D5F69C8BA Q34776238-FF34D15D-332B-4B13-8AEF-B213E6BF5BB3 Q34958437-04EC8583-82A3-4D46-BECF-E4CA052457C3 Q35067713-C7222A60-98D2-45F9-A82C-A8EDCE490AE0

P2860

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

http://www.wikidata.org/entity/Q33816664

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@ast

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@en

type

label

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@ast

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@en

prefLabel

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@ast

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@en

P1433

Q33816664-CA5E15D9-BED3-4D3A-A1BE-E2D81CEFFF04

P1476

Q33816664-C320DB70-9213-49E9-BE14-F3726CA3F9B5

P2093

Q33816664-0FFEB44E-ECB7-4096-808A-39701C981916

Q33816664-1B1DE74C-896C-4787-80F4-8B5BD29F87BC

Q33816664-2BA0010E-27F1-4D35-B18C-2DDCFDFC1E07

Q33816664-803992D8-3D64-4093-9BC5-AF26889E579A

Q33816664-8FC3C389-13F5-4AE6-82F8-8E6423139159

Q33816664-95696C3E-3943-47C0-AE1E-B1CDB124AA9D

Q33816664-A2CFAA24-526E-4D9C-BF36-5CDD146068BA

Q33816664-C0302512-C6C8-4E22-BA4F-87186095FC00

Q33816664-C0699B16-C789-47E9-B582-843D8757E96C

Q33816664-C1075018-FA2A-412F-9D99-EA9B190654FC

P2860

Q33816664-04256E03-C67E-416F-98FF-9589E51F1F11

Q33816664-08FF6947-E45F-4F97-A2B4-09E15332C441

Q33816664-0E9767C2-69BF-4D19-B297-9426DF9A4E13

Q33816664-1999AD64-4576-4D81-BAC3-3C1363B4E8E7

Q33816664-1E8D3DA7-31D6-45FA-A02A-FA8CD87530A8

Q33816664-257C2D80-2C6C-499E-8337-991509C93BDC

Q33816664-4408B84B-25F3-4514-8916-E785C825B46D

Q33816664-5251655E-2291-46E6-B09A-C25216DD1B6A

Q33816664-56E34331-F398-4869-B144-8E84C25E2EF0

Q33816664-5D570D4D-84F5-40A0-A482-B066FC095219

P304

Q33816664-7BA005BA-9CAB-4A10-B28C-3226BF65A268

P31

Q33816664-B3F9E785-BD01-4F7B-925A-17B3CC84D67F

P356

Q33816664-0DAFAA91-F1F6-4ED4-9164-81AD48C27A35

P407

Q33816664-390C561D-64E0-4427-9C41-22CFD53B051F

P433

Q33816664-58E30133-D463-4362-AC0D-5AD050841CC5

P478

Q33816664-DB41C62D-33C9-48EA-B459-75C2042685B6

P50

Q33816664-0CFDF0AA-40D1-429B-BEBF-08A242B91126

Q33816664-6FF7FBAB-DC26-4A7C-8122-788E0030475E

Q33816664-F331E95B-5239-468A-A659-2BD3196CA1BE

P577

Q33816664-22E105BD-CC99-4EAB-9924-A798F476A3C2

P5875

Q33816664-48B3BB00-000D-4D8A-B6F3-48DE3637539E

P698

Q33816664-3499A1B5-08A7-46E0-89BC-28C51DF521FB

P932

Q33816664-AEE4184B-93ED-4F46-BC41-F6A44051839B

P356

J.CUB.2010.02.049

P1433

Current Biology

P1476

Purified TPC isoforms form NAA ...... and endolysosomal trafficking.

@en

P2093

Anthony J Morgan

http://www.w3.org/2001/XMLSchema#string

Emyr Lloyd-Evans

http://www.w3.org/2001/XMLSchema#string

Gary M Wessel

http://www.w3.org/2001/XMLSchema#string

Grant C Churchill

http://www.w3.org/2001/XMLSchema#string

Heidi Koegel

http://www.w3.org/2001/XMLSchema#string

John A Ward

http://www.w3.org/2001/XMLSchema#string

John Parrington

http://www.w3.org/2001/XMLSchema#string

Katja Rietdorf

http://www.w3.org/2001/XMLSchema#string

Keiko Watanabe

http://www.w3.org/2001/XMLSchema#string

Lianne C Davis

http://www.w3.org/2001/XMLSchema#string

P2860

The genome of the sea urchin Strongylocentrotus purpuratus

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

Identification of a chemical probe for NAADP by virtual screening

A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggs

P304

703-709

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CUB.2010.02.049

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

20

http://www.w3.org/2001/XMLSchema#string

P50

Antony Giuseppe Galione

Abdelilah Arredouani

P577

2010-03-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

42609403

http://www.w3.org/2001/XMLSchema#string

P698

20346675

http://www.w3.org/2001/XMLSchema#string

P932

2861162

http://www.w3.org/2001/XMLSchema#string