Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. - Wikidata - awgldk - TriplyDB

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

http://www.wikidata.org/entity/Q33841869

about

A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation Characterization of an alternative splice variant of LKB1 AMPK phosphorylation of raptor mediates a metabolic checkpoint Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation AMP-activated protein kinase, stress responses and cardiovascular diseases Metformin activates AMP kinase through inhibition of AMP deaminase Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1 Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 Regulation of exercise-stimulated glucose uptake in skeletal muscle Influence of Acute and Chronic Exercise on Glucose Uptake Regulation of AMP-activated protein kinase by natural and synthetic activators AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function AMPK: a cellular metabolic and redox sensor. A minireview Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3 Exercise and Regulation of Carbohydrate Metabolism Effects of AMP-activated protein kinase in cerebral ischemia Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4 Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signaling LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis AMPK: a nutrient and energy sensor that maintains energy homeostasis New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis.Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice.AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis.Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.

P2860

Q24293006-7736060C-AC6A-4531-9F0A-F015103ECB37 Q24322647-F13F2955-E721-4977-9764-05B86ACFA068 Q24329244-62BC1DA3-5EC4-47B4-8FB7-C23C3AD21ED9 Q24535576-D1CC0742-A989-4D85-8063-2DEE7AD3DDF6 Q24610297-072A23C9-9E4C-4631-A832-92BD676F4A82 Q24617747-C19206DC-F87B-428F-8AD6-9DA1DDD5BF12 Q24634669-DC9E21DF-7A27-4843-B63D-9D64A16881A8 Q24672153-7FAC29D9-B69E-43BF-805A-2188D26338B1 Q26741327-610D650A-80C7-40DD-BB90-34FBD8662217 Q26748964-93B9180D-8604-4B06-BAD3-D1A61CB90B21 Q26767334-7D8EC5E0-47F1-4939-A719-00A0628447DA Q26865723-8DDE9470-B6CD-4CD6-8FD5-D8987FD18067 Q26995682-B9AEC58E-607B-4B86-AD00-166D51060A91 Q27335445-163AEC63-DDDF-4165-B54E-1C8AC70FB06E Q28085498-3C691336-B2AD-48B0-9AE0-0449003A8CE6 Q28394686-CE192389-36EA-4D84-90C6-8A26C268F668 Q28472548-16D39DC6-91DF-4B25-8AEB-422C41ADBF0B Q28564285-4D0355F3-9161-4AD0-B708-1713BD1DAF2A Q28580464-8C9F2E0B-735E-4BE0-A1F0-D4FDF51563C6 Q28584856-1F742325-E77C-485E-9DD2-38297B74177F Q28584878-B4DD95E2-333D-4C5F-94BC-138B9EFFC87F Q28590162-D939551A-55FA-40AE-8469-9B8ABC3FBCD7 Q28591614-7E20C0E1-DE79-4561-B0AD-F45291596B40 Q28659092-9B666B43-1901-4EB4-B8A0-0984DACF8F23 Q28742048-9B7E8B78-C5A9-4AC3-942C-CC6DEA2AA495 Q29615410-11CE49AF-DFF5-47B4-BB15-1266B7FD5BBA Q30244650-BE0102D4-F96B-4EEE-871C-FD301A2CF6D1 Q30397046-63ECE947-D2F1-44BB-AD2C-5AFE6EFA5BD3 Q30494897-D4226CA0-06C9-4B78-84E1-1A66BD65BEB5 Q33332145-3DCDB32F-F2F3-4D23-A91F-75FDD17E8FB1 Q33402481-9C4961AA-33BF-4368-A582-6FB0E0D788DA Q33573339-154FA06A-1D2C-40C1-9E4E-F986793B3CF9 Q33583058-B0C86016-AC0D-490D-8D1B-9E3E0C8CA3E2 Q33631704-B35C81FC-F3AA-4F54-B1AC-B1C314254DC1 Q33636870-267B1A54-21F2-471F-948D-7DA2CCE1BD66 Q33642900-F98C0880-BA87-4468-9C65-05A0611594EE Q33668140-B83725C4-8244-47D8-8BC4-B70777F8C0B4 Q33747784-8CDBEB3B-D750-4A27-B7BC-11D3AE1E0912 Q33809489-54109F0B-CC02-466F-8918-20201AC083C1 Q33818339-4C87B123-A121-4AE7-A0AE-A03F90965D71

P2860

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

http://www.wikidata.org/entity/Q33841869

description

2005 nî lūn-bûn

@nan

2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@ast

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@en

type

label

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@ast

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@en

prefLabel

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@ast

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@en

P1433

Q33841869-A6356D10-638E-4781-96F1-0A50E588802F

P1476

Q33841869-B945237D-50B8-4DDB-9810-43690B93ED8A

P2093

Q33841869-083A53A3-D4C5-4508-B192-3D70784E89EE

Q33841869-28F045BE-6CB0-4C31-9DEF-2D4308C7B134

Q33841869-5C4BD6F5-306E-4C69-9C65-3B7A831D85FB

Q33841869-A8986BC0-10C2-418B-A23A-CFE7F4B9B867

Q33841869-DCFCB34D-C6DF-447F-A227-A644A6819378

P2860

Q33841869-1BB103A9-FC08-4331-9DA1-4B5116CF2F3C

Q33841869-23E0C55E-FB76-4E8E-874B-7854D9C2B7B4

Q33841869-28E1C873-B843-4B63-B461-508E0EEFCA88

Q33841869-2BD4CCE6-9335-4531-AF37-E08668B8F2BA

Q33841869-2F1D112E-7681-4010-86DE-E292F15B87DA

Q33841869-37C99FDF-F3C9-40F9-93B1-B81AD88CC342

Q33841869-37F57FC1-2D14-4AD8-A6AD-4C22F808D1CC

Q33841869-389EA577-A039-418E-BB34-CA48F311E3A2

Q33841869-5717C54A-58D4-4C60-9991-66153A84E3FC

Q33841869-5B6858A0-8E22-4160-A59B-4A578D5C7737

P304

Q33841869-7AA77B54-A1AE-4934-83DC-E411E6684678

P31

Q33841869-97913C78-3794-4F82-BD8B-08176FE482EF

P356

Q33841869-A0BB0909-E680-441C-832D-F2E0EE1B7529

P407

Q33841869-E6E7EFA8-B572-4FD8-9CB1-913F24CDA483

P433

Q33841869-C86169A2-1C58-4F2D-8199-97C33A24B7EA

P478

Q33841869-C08E7978-1805-4494-9C3B-C339B2B135EF

P50

Q33841869-6C3C469C-7C21-4BB0-8185-F3A6E3481DED

Q33841869-D52C14ED-08E6-4C6D-A8A8-CE21DD8ECE98

P577

Q33841869-A70E04E0-4B1B-45BE-9089-4C71335CAE49

P5875

Q33841869-14332C40-F848-4B01-85DC-9D10528BC8AE

P698

Q33841869-E4E5B21E-A76D-4838-ADB1-B0A5223FB902

P932

Q33841869-B8B47C44-A7A8-4488-8A3E-8CEFE18E07FF

P356

SJ.EMBOJ.7600667

P1433

The EMBO Journal

P1476

Deficiency of LKB1 in skeletal ...... ose uptake during contraction.

@en

P2093

Afshan McCarthy

http://www.w3.org/2001/XMLSchema#string

D Grahame Hardie

http://www.w3.org/2001/XMLSchema#string

Darrin Smith

http://www.w3.org/2001/XMLSchema#string

Kei Sakamoto

http://www.w3.org/2001/XMLSchema#string

Kevin A Green

http://www.w3.org/2001/XMLSchema#string

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Role of AMP-activated protein kinase in mechanism of metformin action

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

Essential role of PDK1 in regulating cell size and development in mice

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

P304

1810-1820

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.EMBOJ.7600667

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

P577

2005-05-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7852453

http://www.w3.org/2001/XMLSchema#string

P698

15889149

http://www.w3.org/2001/XMLSchema#string

P932

1142598

http://www.w3.org/2001/XMLSchema#string