Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. - Wikidata - awgldk - TriplyDB

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.

http://www.wikidata.org/entity/Q33859252

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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders Mechanisms of granulin deficiency: lessons from cellular and animal models Therapeutic and diagnostic challenges for frontotemporal dementia Diagnosis and management of behavioral variant frontotemporal dementia Epigenetics of Alzheimer's disease and frontotemporal dementia Progranulin: at the interface of neurodegenerative and metabolic diseases Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea Progranulin protein levels are differently regulated in plasma and CSF.Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Insights into neuroepigenetics through human histone deacetylase PET imaging.Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells.HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.Progranulin: a growth factor, a novel TNFR ligand and a drug target Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.Epigenetic mechanisms in neurological disease Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.Advances in understanding the molecular basis of frontotemporal dementia.Progranulin: an emerging target for FTLD therapies.Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.Acetyltransferases (HATs) as targets for neurological therapeutics Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers.Promoter DNA methylation regulates progranulin expression and is altered in FTLD.Therapy and clinical trials in frontotemporal dementia: past, present, and future.Progranulin axis and recent developments in frontotemporal lobar degeneration Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management.Progress in frontotemporal dementia research.Presymptomatic studies in genetic frontotemporal dementia.Frontotemporal Lobar Degeneration: Mechanisms and Therapeutic Strategies.Imaging and fluid biomarkers in frontotemporal dementia.

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P2860

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.

http://www.wikidata.org/entity/Q33859252

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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type

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Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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prefLabel

Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

@ast

Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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Suberoylanilide hydroxamic aci ...... ch to frontotemporal dementia.

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Basar Cenik

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Bruce A Posner

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Chantelle F Sephton

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Colleen M Dewey

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Daniel R Dries

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Fen-Biao Gao

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Gang Yu

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Giovanni Coppola

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Joachim Herz

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Kimberley Yu

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P2860

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Structural and functional analysis of a promoter of the human granulin/epithelin gene

HDAC2 negatively regulates memory formation and synaptic plasticity.

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Progranulin: normal function and role in neurodegeneration

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16101-16108

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10.1074/JBC.M110.193433

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18

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286

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Daniel Geschwind

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2011-03-23T00:00:00Z

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21454553

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