Excess beta-catenin promotes accumulation of transcriptionally active p53. - Wikidata - awgldk - TriplyDB

Excess beta-catenin promotes accumulation of transcriptionally active p53.

Excess beta-catenin promotes accumulation of transcriptionally active p53.

http://www.wikidata.org/entity/Q33891005

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GSK-3β: A Bifunctional Role in Cell Death Pathways Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis Early embryonic death in mice lacking the beta-catenin-binding protein Duplin P53 and beta-catenin activity during estrogen treatment of osteoblasts Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells.WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway Beta-catenin--a linchpin in colorectal carcinogenesis?Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2 Activation and activities of the p53 tumour suppressor protein Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene Expression profiling of gastric adenocarcinoma using cDNA array.Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines CK1epsilon is required for breast cancers dependent on beta-catenin activity.Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.Roles of Wnt proteins in neural development and maintenance.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells.The cadherin-catenin adhesion system in signaling and cancer.From p63 to p53 across p73.Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors.Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators.Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma.Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells.Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.Extensive molecular screening for hereditary non-polyposis colorectal cancer

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P2860

Excess beta-catenin promotes accumulation of transcriptionally active p53.

http://www.wikidata.org/entity/Q33891005

description

1999 nî lūn-bûn

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1999 թուականի Յունիսին հրատարակուած գիտական յօդուած

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1999 թվականի հունիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Excess beta-catenin promotes accumulation of transcriptionally active p53.

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

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type

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

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prefLabel

Excess beta-catenin promotes accumulation of transcriptionally active p53.

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

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The EMBO Journal

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Excess beta-catenin promotes accumulation of transcriptionally active p53

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A Damalas

http://www.w3.org/2001/XMLSchema#string

B Geiger

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I Simcha

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J F Leal

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J Zhurinsky

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M Oren

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P2860

Identification of c-MYC as a target of the APC pathway

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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3054-3063

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11

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18

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12940757

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10357817

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1171387

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