Defective DNA replication impairs mitochondrial biogenesis in human failing hearts - Wikidata - awgldk - TriplyDB

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

http://www.wikidata.org/entity/Q33892073

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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond Mitochondria as a therapeutic target in heart failure Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies PGC-1 proteins and heart failure Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis Mitochondrial DNA content contributes to climate adaptation using Chinese populations as a model Genome-wide analysis reveals coating of the mitochondrial genome by TFAM.Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.Increased expression of fatty-acid and calcium metabolism genes in failing human heart.Divergent mitochondrial biogenesis responses in human cardiomyopathy The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.Modulating fatty acid oxidation in heart failure.Glucose metabolism and cardiac hypertrophy Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy.Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.Mechanical unloading promotes myocardial energy recovery in human heart failure.Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease.Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.AMPK isoform expression in the normal and failing hearts.Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure.Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle.AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress Oxygen regulates tissue nitrite metabolism SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression.Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes.The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study.CHIP protects against cardiac pressure overload through regulation of AMPK.Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.Cardiac metabolism in heart failure: implications beyond ATP production.Mitochondrial 8-oxoguanine glycosylase decreases mitochondrial fragmentation and improves mitochondrial function in H9C2 cells under oxidative stress conditions

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P2860

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

http://www.wikidata.org/entity/Q33892073

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

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Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

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type

label

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

@ast

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

@en

prefLabel

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

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Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

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Circulation Research

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Defective DNA replication impairs mitochondrial biogenesis in human failing hearts

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P2093

Federica del Monte

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Georgios Karamanlidis

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Gregory S Couper

http://www.w3.org/2001/XMLSchema#string

Luigino Nascimben

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Prem S Shekar

http://www.w3.org/2001/XMLSchema#string

P2860

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Mitochondrial respiratory-chain diseases

Extension of murine life span by overexpression of catalase targeted to mitochondria

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha.

Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy.

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