A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices.
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Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingTargeting metabotropic glutamate receptors for novel treatments of schizophrenia.mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersGroup I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family.Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Metabotropic glutamate receptors in the trafficking of ionotropic glutamate and GABA(A) receptors at central synapses.Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Investigational NMDA receptor modulators for depression.Glutamate-based anxiolytic ligands in clinical trials.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca(2+) in neurons.Metabotropic glutamate receptor 5 upregulates surface NMDA receptor expression in striatal neurons via CaMKII.Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.Internalization of ionotropic glutamate receptors in response to mGluR activation.Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses.Molecular mechanisms of group I metabotropic glutamate receptor mediated LTP and LTD in basolateral amygdala in vitro.
P2860
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P2860
A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices.
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年論文
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name
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@ast
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@en
type
label
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@ast
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@en
prefLabel
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@ast
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@en
P2093
P2860
P356
P1476
A novel, competitive mGlu(5) r ...... LTP in rat hippocampal slices.
@en
P2093
A E Kingston
A Hargreaves
A J Doherty
D D Schoepp
G L Collingridge
M J Palmer
P L Ornstein
Z A Bortolotto
P2860
P304
P356
10.1038/SJ.BJP.0703574
P407
P577
2000-09-01T00:00:00Z