Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.
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Pharmacological brake-release of mRNA translation enhances cognitive memoryMutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse waysDomains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivoMutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activityStress granules and processing bodies are dynamically linked sites of mRNP remodelingHuman Cytomegalovirus Strategies to Maintain and Promote mRNA Translation'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)Human cytomegalovirus infection activates and regulates the unfolded protein response.Crystal structure of eukaryotic translation initiation factor 2BeIF5 has GDI activity necessary for translational control by eIF2 phosphorylationeIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiationLeukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genesHeme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiencyDCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanismEctopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesisHeme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemiaeIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamicsToll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails.PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alphaLIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Inhibition of host translation by virus infection in vivo.Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses.Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivoThe GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.The mechanism of eukaryotic translation initiation: new insights and challengesThe small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyEIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibitionImpairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients.Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.Abnormal T cell signal transduction in systemic lupus erythematosus.Components of the multifactor complex needed for internal initiation by the IRES of hepatitis C virus in Saccharomyces cerevisiaeExplorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinaseAn eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationStimulators of translation identified during a small molecule screening campaign
P2860
Q21128794-CEB75CCE-B1A1-455D-97FB-7D828B1CCCC3Q24323177-0CD0D3F2-B4C6-45C9-8C59-1A62172E3A06Q24540322-E103FFE7-9FFD-464E-9936-ECB42641D5A9Q24629691-FDFD832A-156D-48D5-883B-11AE88D35B39Q24678779-86E0849E-DC1A-4534-8B6C-81C2AEFD2511Q26752742-782E2B00-EA4B-460B-901D-DC7B653638E7Q26852951-DF2F085F-896A-429A-8BA7-6ECA859D57A9Q27469611-D065CE51-B0E3-406F-8EE8-785E79FE29F9Q27704065-0C76C34E-D786-47B5-B542-4C0C412255D5Q27931061-2481701F-F249-4F58-BAF0-F89488B2A166Q27933768-7B889F3D-293D-47BD-8123-05D664E2048CQ27934320-AB1C5A7C-DB04-4D63-92ED-28117AF90045Q28211740-75F10879-34DD-4FFB-BE60-60D59720B0C1Q28365535-FA94DED0-19C7-4784-AF94-BCA3A151E211Q28474846-F565E8A8-5E89-429F-BDFF-A410092424B8Q28571670-42E791CD-E580-4FFD-9270-563879442DBBQ28592905-E6650DB4-5CBB-466F-8129-ABDC360C549AQ28833240-77D93A76-4C8F-49D5-88FA-7D941A21AF38Q30425800-62D5E610-CB8C-415B-B677-63966EC61FD7Q30433158-239AE570-1C19-478A-9466-A71291D5CACFQ31128979-E0005887-CB3D-4CED-B2D2-703A8A37902DQ33724522-08EC44C2-8743-4515-84C3-E28119A763EEQ33743662-DF7A451D-F54A-4144-9525-0B062EF89010Q33947187-48B17993-CBD4-409A-841F-8B6AD684ABCAQ33948525-08347721-5268-4438-8A32-EAF7A2EB7018Q34006463-4CB8EF63-6D4D-4E2F-A175-258590313E4EQ34012817-0283929A-6F22-407B-9BFC-BFA1CE999CD6Q34118639-268E4DD6-4020-4F42-BE53-79E48411F6A1Q34190226-D4FEB058-3478-4717-A522-6CEA7BA04A74Q34286263-348C7030-F6C4-4FC4-BD0E-72F16DB18280Q34289214-C8A8B90A-340B-42A9-99D7-5F56C8D6216AQ34464670-E630C2BD-371A-4187-A76E-A8024D6995EFQ34500782-BCB98702-232F-44C6-A105-F0191E0A3267Q34674626-FB69DE73-7316-4917-88A1-6156AC6F672EQ34693970-6D3B9E7F-A17D-48A0-9CE8-5F97CF390E7EQ34736534-7221E411-E02E-47AB-B303-EA0B6AD7BE17Q34775434-EADEFB9A-2251-4653-B6E8-9CB6F50F0A97Q35049870-3D44C56C-1A57-4236-AE7F-668CEB4BA2B9Q35065850-1C2705B9-9A7D-4E9C-B81A-3151B16850BFQ35090040-9CD80DAA-9B10-4BA4-8243-5EF03E9AF04C
P2860
Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Tight binding of the phosphory ...... ion of translation initiation.
@ast
Tight binding of the phosphory ...... ion of translation initiation.
@en
type
label
Tight binding of the phosphory ...... ion of translation initiation.
@ast
Tight binding of the phosphory ...... ion of translation initiation.
@en
prefLabel
Tight binding of the phosphory ...... ion of translation initiation.
@ast
Tight binding of the phosphory ...... ion of translation initiation.
@en
P2093
P2860
P1476
Tight binding of the phosphory ...... ion of translation initiation.
@en
P2093
A G Hinnebusch
G D Pavitt
T Krishnamoorthy
P2860
P304
P356
10.1128/MCB.21.15.5018-5030.2001
P407
P50
P577
2001-08-01T00:00:00Z