Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiaeMolecular mechanism of terbinafine resistance in Saccharomyces cerevisiaeRational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approachEmploying information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in Mdr1p of Candida albicansSurface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance.Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transportDivergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeableThe monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor.Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibilityHeterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selectionFK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates of Candida albicans.Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver.Functional characterization of Candida albicans ABC transporter Cdr1p.The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans.Functional expression of heterologous proteins in yeast: insights into Ca2+ signaling and Ca2+-transporting ATPases.Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiaeTranscription factors Asg1p and Hal9p regulate pH homeostasis in Candida glabrata.An update on antifungal targets and mechanisms of resistance in Candida albicans.Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysisRationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.Multidrug resistance in fungiABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transportEfflux-mediated antifungal drug resistance.Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates.Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.Crz1p regulates pH homeostasis in Candida glabrata by altering membrane lipid composition.Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties.The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans.Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition.Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.Targeting efflux pumps to overcome antifungal drug resistance.
P2860
Q27324352-22BE8877-2302-4A24-9398-BD325BB671E5Q27930681-6AA7A115-55DA-4B2B-923A-08D1E78F3445Q27939054-725F6A8F-8B8E-4BFF-9E9E-057ABC3BE0D3Q28472226-CD1EF5AE-1D7C-4DC7-8C97-4F4A32CC9731Q28474339-0A22AA94-DD8A-45E4-A3A3-90CCA2B8E312Q31136813-081CEF56-9F17-4F35-9398-D115C336E552Q33200348-4CE6DF5D-C3D9-4F50-9F28-1D09EA092280Q33560121-085E378F-5275-427C-9636-7A81BA523662Q34049370-7EE4C950-74A4-4800-A96F-B6606B9E5EF9Q34112865-E5A80529-30C3-4652-9D97-3B658F2A6FF1Q34293596-E9EBC37F-20A1-4291-81A3-8B1B31B88085Q34334444-DB266EB5-FB7F-46D1-9019-73BBBE9C688BQ34510707-84EB94EF-625F-4650-AEB0-A154391EE320Q34561878-BAC87B8A-BB40-466E-B8D5-ECB291E083E3Q34793244-B0E8835C-76E9-41FD-ADC6-1D977CF2EE02Q35120697-69D55FF3-1FFC-4118-8140-28F6CF804BD0Q35153712-0A2BEE5E-847F-4BA7-996E-55ADE785866DQ35697281-6CB879A6-7AF1-443D-BF02-3464479C2BE1Q35804176-5F6E2F31-4186-4C39-9439-F6F6DC36DE43Q35861869-5DCEA775-2EF4-4CDE-83B1-09A2B94D3D47Q35947069-DF2494A4-8EC9-44EF-B649-E83D3616B567Q35964153-D09D02EC-0155-4746-A09D-C5A9D3C0FDE7Q36235037-E0AE6C51-962D-4636-B60E-6DC10FBE4155Q36853224-4DE26183-3769-4338-A151-1E814738C1ABQ36910141-6A6EA774-8D33-4416-A0DC-1FB411E343D2Q36943181-852B3DB0-BD1A-4805-82FD-1467FC4F7015Q36949532-B51854A6-725D-4F96-A436-1A487E269A42Q36955059-90612791-0B1B-4FFC-BE8C-D1EBD0C942D6Q37000251-D73E2E95-A666-4FA5-AC60-D02AF437244EQ37156645-A2D912A1-1EBD-4AA0-ABED-0A16959A6A0FQ37274696-2C48076D-7A99-4FF2-95FD-A80BCB9082A0Q37287736-CA6E0544-1C40-49D1-A939-96F5C4CBCC9CQ37337658-EB51F660-F02B-4F56-8B64-F9E7DF517240Q37405366-41A28C97-2B01-4B5C-8F23-7E6F210F100CQ37734737-75681BC4-B959-44A2-86AA-FC061C1C2036Q38362728-A7F290C0-9409-43E2-A24A-AB5012F07943Q38626885-A1839DE4-D86D-4CC8-8F49-F4C7FE28B08DQ38678148-5D254012-371A-48C5-9032-F6AFDA3D8800Q38684284-D60BC003-8FA1-439D-94FA-3622C9FDC350Q38837348-F3CE4C56-E7F7-4685-B8E9-0A5F240CB64D
P2860
Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Functional expression of Candi ...... ient in membrane transporters.
@ast
Functional expression of Candi ...... ient in membrane transporters.
@en
type
label
Functional expression of Candi ...... ient in membrane transporters.
@ast
Functional expression of Candi ...... ient in membrane transporters.
@en
prefLabel
Functional expression of Candi ...... ient in membrane transporters.
@ast
Functional expression of Candi ...... ient in membrane transporters.
@en
P2093
P2860
P1476
Functional expression of Candi ...... ient in membrane transporters.
@en
P2093
A Decottignies
A R Holmes
K Nakamura
R D Cannon
P2860
P304
P356
10.1128/AAC.45.12.3366-3374.2001
P407
P577
2001-12-01T00:00:00Z