Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation.
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Highlights on distinctive structural and functional properties of HTLV Tax proteinsThe HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects?HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin ChainsTax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein.Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway.An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.A non-SUMOylated tax protein is still functional for NF-κB pathway activation.Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemiaGenotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanismRole of post-translational modifications of HTLV-1 Tax in NF-κB activation.Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisSuppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein TaxHuman T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.Move or die: the fate of the Tax oncoprotein of HTLV-1.The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesisProgressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing.The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activationHTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysUbiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export.Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein.Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast modelPDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradationHTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165Ubiquitin in NF-kappaB signaling.HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replicationNF-κB as a target for oncogenic viruses.HTLV gene regulation: because size matters, transcription is not enough.Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.Viral takeover of the host ubiquitin system.Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.Anti-apoptotic effect of Tax: an NF-κB path or a CREB way?Animal models on HTLV-1 and related viruses: what did we learn?
P2860
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P2860
Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@ast
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@en
type
label
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@ast
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@en
prefLabel
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@ast
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@en
P2093
P50
P1433
P1476
Tax ubiquitylation and sumoyla ...... steps of NF-kappaB activation.
@en
P2093
Estelle Chiari
Maher Abdulhay
Marwan El-Sabban
Rihab Nasr
Victor Yazbeck
Youmna Kfoury
P304
P356
10.1182/BLOOD-2005-09-3572
P407
P577
2006-01-19T00:00:00Z