PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
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The Ubiquitination of NF-κB Subunits in the Control of TranscriptionEpigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer.An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.The transcription profile of Tax-3 is more similar to Tax-1 than Tax-2: insights into HTLV-3 potential leukemogenic properties.DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic targetThe four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoproteinHuman T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisSuppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor κB (NF-κB) and STAT3 transcription factors for tumorigenesis and tumor maintenance.NF-κB and cancer: a paradigm of Yin-Yang.Making sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs).Move or die: the fate of the Tax oncoprotein of HTLV-1.Differential roles of STAT3 in the initiation and growth of lung cancerEmerging theme: cellular PDZ proteins as common targets of pathogenic viruses.The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesisInterleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function.HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathwaysPDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor αThe HBZ gene, a key player in HTLV-1 pathogenesis.Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replicationHuman T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax.Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.Human T-lymphotropic virus proteins and post-translational modification pathwaysViral lymphomagenesis: from pathophysiology to the rationale for novel therapies.Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation?Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis.Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling.Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.HBZ and its roles in HTLV-1 oncogenesis.Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia.Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation.
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PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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PDLIM2 suppresses human T-cell ...... ix for proteasomal degradation
@en
PDLIM2 suppresses human T-cell ...... x for proteasomal degradation.
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type
label
PDLIM2 suppresses human T-cell ...... ix for proteasomal degradation
@en
PDLIM2 suppresses human T-cell ...... x for proteasomal degradation.
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prefLabel
PDLIM2 suppresses human T-cell ...... ix for proteasomal degradation
@en
PDLIM2 suppresses human T-cell ...... x for proteasomal degradation.
@nl
P2093
P2860
P1433
P1476
PDLIM2 suppresses human T-cell ...... ix for proteasomal degradation
@en
P2093
Gutian Xiao
Michael J Grusby
Shirong Li
Takashi Tanaka
Zhaoxia Qu
P2860
P304
P356
10.1182/BLOOD-2008-10-185660
P407
P577
2009-01-08T00:00:00Z