T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity
about
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiationPhosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongationA uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregationKin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation.MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functionsMolecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoCyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cellsCDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction pointFunctional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryosGlobal gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domaincdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutationsCyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivoAnalogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.The CDK Network: Linking Cycles of Cell Division and Gene Expression.A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progressionDistinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cellsCyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase IIThe lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts.Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.Protein Phosphatase-1 Regulates Expression of Neuregulin-1.CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation.Novel potent pharmacological cyclin-dependent kinase inhibitors.Cyclin-dependent kinase modulators and cancer therapy.Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycleBRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha.Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, HidCharacterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation.Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
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P248
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P2860
T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@ast
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@en
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@nl
type
label
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@ast
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@en
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@nl
prefLabel
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@ast
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@en
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@nl
P2093
P2860
P50
P356
P1433
P1476
T-loop phosphorylation stabili ...... ulates its CTD kinase activity
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.14.3749
P407
P577
2001-07-01T00:00:00Z