A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression - Wikidata - awgldk - TriplyDB

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

http://www.wikidata.org/entity/Q36916346

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Getting to S: CDK functions and targets on the path to cell-cycle commitment TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.Targeting transcription regulation in cancer with a covalent CDK7 inhibitor The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.Pause, play, repeat: CDKs push RNAP II's buttons.How the cell cycle impacts chromatin architecture and influences cell fate.The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network.JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.The CDK-activating kinase Cdk7: taking yes for an answer.Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.The essential and multi-functional TFIIH complex.The Temporal Regulation of S Phase Proteins During G1.Xeroderma Pigmentosum Group D (XPD) Inhibits the Proliferation Cycle of Vascular Smooth Muscle Cell (VSMC) by Activating Glycogen Synthase Kinase 3β (GSK3β)Structural insights into the functional diversity of the CDK-cyclin family

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P2860

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

http://www.wikidata.org/entity/Q36916346

description

2013 nî lūn-bûn

@nan

2013年の論文

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2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

@en

type

label

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

@en

prefLabel

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

@en

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J.MOLCEL.2013.04.003

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A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression

@en

P2093

Alexander Hirschi

http://www.w3.org/2001/XMLSchema#string

Chao Zhang

http://www.w3.org/2001/XMLSchema#string

Karl A Merrick

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Miriam Merzel Schachter

http://www.w3.org/2001/XMLSchema#string

Robert P Fisher

http://www.w3.org/2001/XMLSchema#string

Seth M Rubin

http://www.w3.org/2001/XMLSchema#string

Stéphane Larochelle

http://www.w3.org/2001/XMLSchema#string

P2860

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release

New functional activities for the p21 family of CDK inhibitors

Structural basis of cyclin-dependent kinase activation by phosphorylation

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH

A restriction point for control of normal animal cell proliferation

Crystal structure of human CDK4 in complex with a D-type cyclin

The structure of CDK4/cyclin D3 has implications for models of CDK activation

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250-260

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10.1016/J.MOLCEL.2013.04.003

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2

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50

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2013-04-01T00:00:00Z

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23622515

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phosphorylation

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3677717

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