The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsMHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cellsAntigenic peptide trimming by ER aminopeptidases--insights from structural studiesWhat is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptideStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingStructural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationmicroRNAs function in CD8+T cell biologyERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumProteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cellsIdentification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cellsIdentification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association studyInteraction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradationA detailed analysis of the murine TAP transporter substrate specificityThe internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeThe specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationEndoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.Microarray analysis of differential gene expression profile in peripheral blood cells of patients with human essential hypertension.Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.Proteases in MHC class I presentation and cross-presentationThe carboxypeptidase ACE shapes the MHC class I peptide repertoireMajor histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesAssociation of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib moleculesERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han populationStructural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1
P2860
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P2860
The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.
description
2005 nî lūn-bûn
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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@ast
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@en
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@nl
type
label
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@ast
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@en
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@nl
prefLabel
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@ast
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@en
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism.
@nl
P2093
P2860
P356
P1476
The ER aminopeptidase, ERAP1, ...... a "molecular ruler" mechanism
@en
P2093
Alfred L Goldberg
Frank Momburg
Nidhi Bhutani
P2860
P304
17107-17112
P356
10.1073/PNAS.0500721102
P407
P577
2005-11-14T00:00:00Z