Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.
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Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing preyCooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinThe evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey.Computational studies of marine toxins targeting ion channelsIn silico analysis of putative paralytic shellfish poisoning toxins export proteins in cyanobacteriaA molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelCharacterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticidesConvergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis.Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1).Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesToxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data.Use of venom peptides to probe ion channel structure and function.KvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experimentsIdentification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels.Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.Molecular biology of insect sodium channels and pyrethroid resistance.Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]Trans-channel interactions in batrachotoxin-modified skeletal muscle sodium channels: voltage-dependent block by cytoplasmic amines, and the influence of mu-conotoxin GIIIA derivatives and permeant ionsMutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.A stereoselective synthesis of (+)-gonyautoxin 3.Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications.Indoxacarb, Metaflumizone, and Other Sodium Channel Inhibitor Insecticides: Mechanism and Site of Action on Mammalian Voltage-Gated Sodium Channels.Selectivity and cooperativity of modulatory ions in a neurotransmitter receptorThe tetrodotoxin binding site is within the outer vestibule of the sodium channel.On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin.NaChBac: the long lost sodium channel ancestorAdvances in targeting voltage-gated sodium channels with small molecules.Saxitoxin.Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels.Determinants of Cation Permeation and Drug Sensitivity in Predicted Transmembrane Helix 9 and Adjoining Exofacial Re-entrant Loop 5 of Na+/H+ Exchanger NHE1.Structural model for dihydropyridine binding to L-type calcium channels.Sodium channels: ionic model of slow inactivation and state-dependent drug binding.Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channelsThermal and chemical unfolding and refolding of a eukaryotic sodium channel
P2860
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P2860
Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Modeling P-loops domain of sod ...... and interaction with ligands.
@en
type
label
Modeling P-loops domain of sod ...... and interaction with ligands.
@en
prefLabel
Modeling P-loops domain of sod ...... and interaction with ligands.
@en
P2860
P1433
P1476
Modeling P-loops domain of sod ...... and interaction with ligands.
@en
P2093
Boris S Zhorov
Denis B Tikhonov
P2860
P304
P356
10.1529/BIOPHYSJ.104.048173
P407
P577
2004-10-08T00:00:00Z