A reinterpretation of the dimerization interface of the N-terminal domains of STATs
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Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domainMolecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding SitesDetermination of Multicomponent Protein Structures in Solution Using Global Orientation and Shape RestraintsSTAT4 requires the N-terminal domain for efficient phosphorylationStructure of the unphosphorylated STAT5a dimer.Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila.The different functions of Stat5 and chromatin alteration through Stat5 proteinsAlternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation.Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomasDNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers.Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional ActivitySignal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity.Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapyThe STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.Role of different regions of the hepatitis C virus genome in the therapeutic response to interferon-based treatment.Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation.IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domainPre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.Elevated activity of STAT3C due to higher DNA binding affinity of phosphotyrosine dimer rather than covalent dimer formation.Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain.Crystallization and X-ray crystallographic analysis of human STAT1.Critical residue that promotes protein dimerization: a story of partially exposed Phe25 in 14-3-3σ.Structural characterization of unphosphorylated STAT5a oligomerization equilibrium in solution by small-angle X-ray scattering.A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors.Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment.Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development.
P2860
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P2860
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@ast
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@en
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@nl
type
label
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@ast
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@en
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@nl
prefLabel
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@ast
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@en
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@nl
P2093
P2860
P356
P1433
P1476
A reinterpretation of the dimerization interface of the N-terminal domains of STATs
@en
P2093
Focco Van Den Akker
James E Darnell
John Kuriyan
Xiaomin Chen
P2860
P304
P356
10.1110/PS.0218903
P577
2003-02-01T00:00:00Z