Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.
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Intracellular domains interactions and gated motions of I(KS) potassium channel subunitsInactivation as a new regulatory mechanism for neuronal Kv7 channelsPI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric vein.Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium.The KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitabilityRegulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Analysis of phosphatidylinositol-4,5-bisphosphate signaling in cerebellar Purkinje spinesPurinergic signaling in the inner ear.KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation.A phospholipid sensor controls mechanogating of the K+ channel TREK-1.Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytesStructural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanningPhosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channelKCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.The KCNQ1 potassium channel: from gene to physiological function.Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelPhosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells.Computational biology in the study of cardiac ion channels and cell electrophysiology.Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytesOpposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Regulation of voltage-gated potassium channels by PI(4,5)P2PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker.Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels.KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channelsWhy biophysicists make models: quantifying modulation of the M currentRegulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq.What determines the kinetics of the slow afterhyperpolarization (sAHP) in neurons?Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks)Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathwayAbscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis linesTarget-specific PIP(2) signalling: how might it work?A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels.
P2860
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P2860
Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
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name
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@ast
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@en
type
label
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@ast
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@en
prefLabel
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@ast
Phosphatidylinositol-4,5-bisph ...... inward rectifier K+ channels.
@en
P2093
P2860
P50
P356
P1433
P1476
Phosphatidylinositol-4,5-bisph ...... d inward rectifier K+ channels
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/CDG526
P407
P577
2003-10-01T00:00:00Z