The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression
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Adenovirus early region 4 stimulates mRNA accumulation via 5' introns.Induced expression of the endogenous beta interferon gene in adenovirus type 5-transformed rat fibroblaststrans-dominant interference of type 5 adenovirus E1a mutants in cell transformationAdenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transitionAnalysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.Defective expression of adenovirus genes during early infection of undifferentiated OTF963 embryonal carcinoma cells.Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activityThe state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function.The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter.The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcriptionActivation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product.The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression.Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters.
P2860
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P2860
The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The cellular transcription fac ...... adenovirus E2A gene expression
@en
type
label
The cellular transcription fac ...... adenovirus E2A gene expression
@en
prefLabel
The cellular transcription fac ...... adenovirus E2A gene expression
@en
P2860
P1433
P1476
The cellular transcription fac ...... adenovirus E2A gene expression
@en
P2093
L E Babiss
P2860
P304
P407
P577
1989-06-01T00:00:00Z