Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.
about
IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagyDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleThe immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell deathTargeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagyStriking the Right Balance Determines TB or Not TBInflammatory stimuli reprogram macrophage phagocytosis to macropinocytosis for the rapid elimination of pathogensRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiInactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoRegulation of macrophage motility by Irgm1Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?The role of the activated macrophage in clearing Listeria monocytogenes infectionp47 GTPases regulate Toxoplasma gondii survival in activated macrophages.Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease.Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cellsInterferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosisMycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.Anamnestic responses of mice following Mycobacterium tuberculosis infection.Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.Cell-autonomous effector mechanisms against mycobacterium tuberculosis.Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human diseaseType I interferons link viral infection to enhanced epithelial turnover and repair.Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity.Irgm1 protects hematopoietic stem cells by negative regulation of IFN signalingThe immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashionLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.Vaccines for tuberculosis: novel concepts and recent progress.Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.C-type lectins with a sweet spot for Mycobacterium tuberculosis.IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection.Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.Innate immune effectors in mycobacterial infection.Comparative genomic analysis of eutherian interferon-γ-inducible GTPases.Host-directed therapeutics for tuberculosis: can we harness the host?
P2860
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P2860
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@ast
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@en
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@nl
type
label
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@ast
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@en
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@nl
prefLabel
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@ast
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@en
Mice deficient in LRG-47 displ ...... the induction of lymphopenia.
@nl
P2093
P1476
Mice deficient in LRG-47 displ ...... h the induction of lymphopenia
@en
P2093
Carmen M Collazo-Custodio
Dragana Jankovic
Gregory A Taylor
Karen Elkins
Michael Eckhaus
Sara Hieny
Yasmine Belkaid
P304
P356
10.4049/JIMMUNOL.172.2.1163
P407
P50
P577
2004-01-01T00:00:00Z