Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
about
A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liverDisruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathIFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagyLocalisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsImmune response and immunopathology during toxoplasmosisCoordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuolePhosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceThe activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiInterferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagyDeterminants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control itIdentification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance systemMAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in miceThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Invited review: Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamilyPhosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiA Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsInactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoA family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionRegulation of macrophage motility by Irgm1The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infectionsInterferon-inducible effector mechanisms in cell-autonomous immunity.The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.Subversion of host cellular functions by the apicomplexan parasites.Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylationAutophagy in immunity and cell-autonomous defense against intracellular microbesGuanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteinsNitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.Self and non-self discrimination of intracellular membranes by the innate immune system.ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fissionIrgm1 protects hematopoietic stem cells by negative regulation of IFN signalingToxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.
P2860
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P2860
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
description
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Oktober 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/10/08)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/10/08)
@nl
наукова стаття, опублікована в жовтні 2008
@uk
مقالة علمية (نشرت في 8-10-2008)
@ar
name
Regulatory interactions betwee ...... response to Toxoplasma gondii
@ast
Regulatory interactions betwee ...... response to Toxoplasma gondii
@en
Regulatory interactions betwee ...... response to Toxoplasma gondii
@nl
type
label
Regulatory interactions betwee ...... response to Toxoplasma gondii
@ast
Regulatory interactions betwee ...... response to Toxoplasma gondii
@en
Regulatory interactions betwee ...... response to Toxoplasma gondii
@nl
prefLabel
Regulatory interactions betwee ...... response to Toxoplasma gondii
@ast
Regulatory interactions betwee ...... response to Toxoplasma gondii
@en
Regulatory interactions betwee ...... response to Toxoplasma gondii
@nl
P2093
P2860
P3181
P356
P1433
P1476
Regulatory interactions betwee ...... response to Toxoplasma gondii
@en
P2093
Frank Kaiser
Jens Zerrahn
Julia P Hunn
Natasa Papic
Nikolaus Pawlowski
Nina Schroeder
Rita Lange
Sascha Martens
Stephanie Koenen-Waisman
P2860
P304
P3181
P356
10.1038/EMBOJ.2008.176
P407
P577
2008-09-04T00:00:00Z