Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells.
about
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoterRestoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier functionBiology of the major facilitative folate transporters SLC19A1 and SLC46A1The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transportersFunctional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair associationTopological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertionRepression of human reduced folate carrier gene expression by wild type p53.Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrierOne-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over theMolecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis.Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells.The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.SLC19A1 pharmacogenomics summary.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterLocalization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.The emergence of resistance to targeted cancer therapeutics.Resistance to antifolates.Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transEffects of 5' untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier.Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Polymorphisms and methylation of the reduced folate carrier in osteosarcoma.A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder.Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function.Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyRole of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition.Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate tRegulation of folate receptor 1 gene expression in the visceral endoderm.Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Structural organization of the reduced folate carrier gene in Chinese hamster ovary cells.Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods.
P2860
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P2860
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@ast
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@en
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@nl
type
label
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@ast
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@en
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@nl
prefLabel
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@ast
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@en
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@nl
P2093
P356
P1476
Isolation of human cDNAs that ...... e Chinese hamster ovary cells.
@en
P2093
L H Matherly
S A Proefke
P304
17468-17475
P356
10.1074/JBC.270.29.17468
P407
P577
1995-07-01T00:00:00Z